Spontaneous and Evoked NMDA-Receptor Mediated Potentials in the Entorhinal Cortex of the Neonate Rat in Vitro
It is becoming clear that amino acid receptors of the N-methyl-D-aspartate (NMDA) subtype show changes in number or sensitivity during early development. During the first two weeks of life in the rat there is a decline in sensitivity of the cell soma of CA1 neurones to NMDA and a concurrent enhancement of dendritic responsiveness1. During the same period cerebellar Purkinje cells show a progressive enhancement enhancement of sensitivity to NMDA which then declines with further development2,3. Visual cortical cells in the cat also appear to show a declining responsiveness to NMDA during early development4.
KeywordsNMDA Receptor Dentate Gyrus Entorhinal Cortex Synaptic Response Perforant Path
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