Topographical Heterogeneity of Glutamate Agonist-Induced Calcium Increase in Hippocampus
Although the mechanisms underlying the establishment of long term potentiation (LTP) in the hippocampus have not been understood yet, it is widely accepted that the increase in intracellular Ca2+ concentration ([Ca2+]i) due to the activation of L-glutamate receptors plays a crucial role in the early phase of LTP (Kudo et al., 1987; Malenka et al., 1988). It is therefore important to specify the location of L-glutamate receptors responsible for the [Ca2+]i elevation.
KeywordsMossy Fiber Population Spike Slice Preparation Tetanic Stimulation Schaffer Collateral
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