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Characterization of Membranal and Purified NMDA Receptors

  • A. F. Ikin
  • V. Nadler
  • Y. Kloog
  • M. Sokolovsky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 268)

Abstract

Over the past years considerable progress has been made towards understanding the biochemical and physiological significance of the N-methyl-D-aspartate (NMDA) type of excitatory amino acid receptor (for review see Cotman & Iversen, 1987). Receptor binding and electrophysiological studies have indicated that the NMDA-receptor complex comprises a number of distinct structural domains through which its function may be regulated or pharmacologically modified. The domains identified so far are: (i) the glutamate-binding site; (ii) an allosteric site, where glycine and/or 1-aminocyclopropane-l-carboxylic acid (ACC) regulate agonist-induced channel opening; (iii) a site (or sites) through which Mg2+ modulates the passage of ions; (iv) a site or sites that recognizes Zn2+ and prevents channel activation, and (v) a site or sites within the receptor channel for binding of drugs such as phencyclidine (PCP)-like, MK-801 and ketamine.

Keywords

NMDA Receptor Sodium Cholate Excitatory Amino Acid Receptor Photoaffinity Label Label Ligand 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • A. F. Ikin
    • 1
  • V. Nadler
    • 1
  • Y. Kloog
    • 1
  • M. Sokolovsky
    • 1
  1. 1.Laboratory of Neurobiochemistry, Department of Biochemistry, Faculty of Life SciencesTel Aviv UniversityTel AvivIsrael

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