Evidence for Glutamate Receptor Subtypes from in Vivo Electrophysiology: Studies with HA-966, Quinoxalinediones and Philanthotoxin

  • David Lodge
  • Martyn G. Jones
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 268)


In this chapter we will briefly review some of the evidence from electrophysiological studies of mammalian neurones in vivo which relates to the subtypes of glutamate receptors. In particular we will concentrate on recent experiments elucidating the mechanism of action of HA-966 as an N-methyl-D-aspartate (NMDA) antagonist and of a new tricyclic quinoxalinedione (NBQX) and a wasp venom, philanthotoxin, as quisqualate antagonists. These studies were designed to test the hypothesis that the NMDA subtype and one other non-NMDA subtype of glutamate receptor mediate the excitation of rat spinal and brainstem neurones produced by acidic amino acids.


Excitatory Amino Acid Excitatory Amino Acid Receptor Mammalian Neurone Brainstem Neurone Wasp Venom 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • David Lodge
    • 1
  • Martyn G. Jones
    • 1
  1. 1.Department of Veterinary Basic SciencesRoyal Veterinary CollegeLondonUK

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