Advertisement

Evidence for Glutamate Receptor Subtypes from in Vivo Electrophysiology: Studies with HA-966, Quinoxalinediones and Philanthotoxin

  • David Lodge
  • Martyn G. Jones
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 268)

Abstract

In this chapter we will briefly review some of the evidence from electrophysiological studies of mammalian neurones in vivo which relates to the subtypes of glutamate receptors. In particular we will concentrate on recent experiments elucidating the mechanism of action of HA-966 as an N-methyl-D-aspartate (NMDA) antagonist and of a new tricyclic quinoxalinedione (NBQX) and a wasp venom, philanthotoxin, as quisqualate antagonists. These studies were designed to test the hypothesis that the NMDA subtype and one other non-NMDA subtype of glutamate receptor mediate the excitation of rat spinal and brainstem neurones produced by acidic amino acids.

Keywords

Excitatory Amino Acid Excitatory Amino Acid Receptor Mammalian Neurone Brainstem Neurone Wasp Venom 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Anis, N.A, Berry, S.C., Burton, N.R. and Lodge, D. The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methylaspartate. Br J Pharmacol 1983; 79: 565–575.PubMedCrossRefGoogle Scholar
  2. Aram. J.A., Martin, D., Tomcczyk, M., Zeman, S., Millar, J., Pohler, G. and Lodge, D. Neocortical epileptogenesis in vitro: studies with N-methyl-D-aspartate, phencyclidine, sigma and dextromethorphan receptor ligands. J Pharm Exp Ther 1989; 248: 320–328.Google Scholar
  3. Ault, B, Evans, R.H., Francis, A.A., Oakes, D.J. and Watkins, J.C. Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations. J Physiol 1980; 307: 413–428.PubMedGoogle Scholar
  4. Birch, P.J., Grossman, C.J. and Hayes, A.G. Kynurenate and FG9041 have both competitive and non-competitive actions at excitatory amino acid receptors. Eur. J. Pharmacol 1988; 151: 313–315.PubMedCrossRefGoogle Scholar
  5. Cull-Candy, S.G. and Usowicz, M.M. Multiple conductance channels activated by excitatory amino acids in cerebellar neurones. Nature 1987; 325: 527–528.CrossRefGoogle Scholar
  6. Curtis, D.R. and Watkins, J.C. Acidic amino acids with strong excitatory actions on mammalian neurones. J Physiol 1963; 166: 1–14.PubMedGoogle Scholar
  7. Davies, J. and Watkins, J.C. Is 1-hydroxy-3-amino-pyrrolidone-2 (HA966) a selective excitatory amino acid antagonist? Nature New Biol 1972; 328: 61–63.Google Scholar
  8. Eldefrawi, A.T., Eldefrawi, M.E., Konno, K., Mansour, N.A., Nakanishi, K., Oltz, E. and Usherwood, P.N.R. Structure and synthesis of a potent glutamate receptor antagonist in wasp venom. Proc Natl Acad Sci USA 1988; 85: 4910–4913.PubMedCrossRefGoogle Scholar
  9. Fletcher, E.J. and Lodge, D. Glycine reverses antagonism of N-methyl-D-aspartate (NMDA) by 1-hydroxy-3-pyrrolidone-2 (HA-966) but not by D-2-amino-5-phosphonovalerate (D-AP5) on rat cortical slices. Eur J Pharm 1988; 151: 161–162.CrossRefGoogle Scholar
  10. Fletcher, E.J., Millar, J.D., Zeman, S. and Lodge, D. Non-competitive antagonism of N-methyl-D-aspartate by displacement of an endogenous glycine-like substance. Eur J Neurosci 1989; 1: 196–203.PubMedCrossRefGoogle Scholar
  11. Foster, A.C. and Fagg, G.E. Acidic amino acid binding sites in mammalian neuronal membranes: their characteristics and relationships to synaptic receptors. Brain Res Rev 1984; 7: 103–164.CrossRefGoogle Scholar
  12. Honore, T., Davies, S.N., Drejer, J., Fletcher, E.J., Jacobsen, Lodge, D. and Nielsen, F. E. Quinoxalinediones: Potent competitive non-NMDA glutamate receptor antagonists. Science 1988; 241: 701–703.Google Scholar
  13. Jackson, H. and Usherwood, P.N.R. Spider toxins as tools for dissecting elements of excitatory amino acid transmission. Trends Neurosci 1988; 11: 278–283.PubMedCrossRefGoogle Scholar
  14. Jahr, C.E. and Stevens, C.F. Glutamate activates multiple single channel conductances in hippocampal neurones. Nature 1987; 325: 522–525.PubMedCrossRefGoogle Scholar
  15. Johnson J.W. and Ascher P. Glycine potentiates the NMDA response in cultured mouse brain neurones. Nature 1987; 325: 529–531PubMedCrossRefGoogle Scholar
  16. Kerry, C.J., Ramsey, R.L., Sansom, M.S.P. and Usherwood, P.N.R. Single channel studies on non-competetive antagonists of a quisqualatesensitive glutamate receptor by argiotoxin636- a fraction isolated from the orb-weaver spider venom. Brain Res 1988; 459: 312–327.PubMedCrossRefGoogle Scholar
  17. Kessler, M., Baudry, M., Terramani, T. and Lynch, G. Complex interactions between a glycine binding site and NMDA receptors. Soc Neurosci Abstr 1987; 13: 760.Google Scholar
  18. Krogsgaard-Larsen, P., Honore, T., Hansen, J.J., Curtis, D.R. and Lodge, D. New class of glutamate agonist structurally related to ibotenic acid. Nature; 1980: 284: 64–66.PubMedCrossRefGoogle Scholar
  19. Lodge, D. and Anis, N.A. Effects of phencyclidine on excitatory amino acid acid activation of spinal interneurones in the cat. Eur J Pharmacol 1982; 77: 203–204.PubMedCrossRefGoogle Scholar
  20. Lodge, D. Aram, J.A., Church, J., Davies, S.N., Martin, D., Millar, J. and Zeman, S. Sigma opiates and excitatory amino acids. In: Excitatory Amino Acids in Health and Disease. Ed. D. Lodge. John Wiley, London. 1988; pp. 237–259.Google Scholar
  21. Lodge, D. and Johnson, K.M. Non-competitive excitatory amino acid antagonists. Trends Pharm Sci 1990; in press.Google Scholar
  22. Loo, P., Braunwalder, A., Lehmann, J. and Williams, M. Radioligand binding to central phencyclidine recognition sites is dependent on excitatory amino acid receptor agonists. Eur J Pharmacol 1986; 123: 467–468.PubMedCrossRefGoogle Scholar
  23. Martin, D and Lodge, D. Phencyclidine receptors and N-methyl-D-aspartate antagonism: Electrophysiologic data correlates with known behaviours. Pharmacol Biochem Behav 1989; 31: 279–286.CrossRefGoogle Scholar
  24. Mayer,2+., Westbrook, G.L. and Guthrie, P.B. Voltage-dependent block by Mg of NMDA responses in spinal cord neurones. Nature 1984; 309: 261–263.Google Scholar
  25. McLennan, H. Receptors for excitatory amino acids in the mammalian central nervous system. Prog Neurobiol 1983; 20: 251–271.PubMedCrossRefGoogle Scholar
  26. Nowak, L. Bregestovski, P., Ascher, P., Herbet, A. and Prochiantz, A. Magnesium gates glutamate-activated channels in mouse central neurones Nature 1984; 307: 462–465.PubMedCrossRefGoogle Scholar
  27. Ornstein, P.L., Schoeppe, D.D., Leander, J.D., Wong, D.T., Lodge, D. and Mason, N.R. In vitro and in vivo characterization of LY233O53: a structurally novel competitive antagonist. Soc Neurosci Abstr 1989; in press.Google Scholar
  28. Saito, M., Kawai, N., Miwa, A., Pan-Hou, H and Yoshioka, M. Spider toxin (JSTX) blocks glutamate synapse in hippocampal pyramidal neurons. Brain Res 1985; 346: 397–399.PubMedCrossRefGoogle Scholar
  29. Simmonds, M.A. and Horne, A.L. Antagonism of excitatory amino acids by barbiturates. In: Excitatory Amino Acids in Health and Disease, Ed. D. Lodge. John Wiley, London. 1988; pp. 219–237.Google Scholar
  30. Watkins, J.C. and Collingridge, G.L. (Eds) The NMDA Receptor. Oxford Univ Press. 1989; in press.Google Scholar
  31. Watkins J.C. and Evans R.H. Excitatory amino acid transmitters. Annu Rev Pharm Tox 1981; 21: 165–204.CrossRefGoogle Scholar
  32. Watkins, J.C., Krogsgaard-Larsen, P. and Honore, T. Structure-activity relations in the development of excitatory amino acid receptor antagonists. Trends Pharm Sci 1990; in press.Google Scholar
  33. Watkins, J.C. and Olverman, H. Structural requirements for activation and blockade of EAA receptors. In: Excitatory Amino Acids in Health and Disease, Ed. D. Lodge. John Wiley, London. 1988; pp. 13–45.Google Scholar
  34. Wong, E.H.F., Kemp, J.A., Priestley, T., Knight, A.R., Woodruff, G.N. and Iversen, L.L. The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci USA 1986; 83: 7104–7108.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • David Lodge
    • 1
  • Martyn G. Jones
    • 1
  1. 1.Department of Veterinary Basic SciencesRoyal Veterinary CollegeLondonUK

Personalised recommendations