The Use of Hyperthermia in Cancer Treatment

An Analysis of Clinical Investigations on Deep Seated Malignant Tumor Control with a Radiofrequency Capacitive Hyperthermia System (Thermotron RF-8)
  • U. Raymond
  • Tsutomu Sugahara
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 267)


In response to the challenge of treating deep-seated tumors without undue damage to surrounding normal tissues, a radiofrequency (RF) capacitive heating system known as the Thermotron RF-8 (Yamamoto Vinyter Co., Osaka), with its many innovative engineering remedies, was developed, and it has enabled multi-institutional controlled clinical hyperthermia trials targeted to major organ site neoplasms, i.e. lung cancer, pancreatic cancer, gastric cancer, hepatocellular cancer, rectal cancer, urinary bladder cancer, etc.


Urinary Bladder Cancer Minor Regression Degradable Starch Microsphere Performance Status Improvement Favorable Response Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Abe M, Hiraoka M, Takahashi M, Egawa S, Matsuda T, Onoyama Y, Morita K, Kakehi M and Sugahara T: Multi–institutional studies on hyperthermia using an 8–MHZ radiofrequency capacitive heating device (Thermotron RF–8) in combination with radiation for cancer therapy. Cancer 58: 1589–1595, 1986.PubMedCrossRefGoogle Scholar
  2. 2.
    Hiraoka M, Jo S, Akuta K, Nishimura Y, Takahashi M and Abe M: Radiofrequency capacitive hyperthermia for deep–seated tumors. I. Studies on thermometry. Cancer 60: 121–127, 1987.PubMedCrossRefGoogle Scholar
  3. 3.
    Hiraoka M, Jo S, Akuta K, Nishimura Y, Takahashi M and Abe M: Radiofrequency capacitive hyperthermia for deep–seated tumors. H. Effects of thermoradiotherapy. Cancer 60: 128–135, 1987.PubMedCrossRefGoogle Scholar
  4. 4.
    Hiraoka M, Jo S, Dodo Y, Ono K, Takahashi M, Nishida H and Abe M: Clinical Results of radiofrequency hyperthermia combined with radiation in the treatment of radioresistant cancers. Cancer 54: 2898–2904, 1984.PubMedCrossRefGoogle Scholar
  5. 5.
    Hiraoka M, Jo S, Takahashi M and Abe M: Thermometry results of RF capacitive heating for human deep–seated tumors. In: Overgaard J, ed. Proceedings of the 4th International Symposium on Hyperthermic Oncology. London: Talor & Francis, 1984, pp. 803–806.Google Scholar
  6. 6.
    Kakehi M, Ueda K, Mukojima T, Hiraoka M, Seto 0, Akanuma A and Nakatsugawa S: Multi–institutional clinical studies on hyperthermia combined with radiotherapy or chemotherapy in advanced cancers. Int J Hyperthermic Oncol: In Press.Google Scholar
  7. 7.
    Kato H, Hiraoka M, Nakajima T and Ishida T: Deep–heating characteristics of an RF capacitive heating device. Int J Hyperthermia is 15–28, 1985.Google Scholar
  8. 8.
    Kodama K, Doi 0, Tatsuta M, Kuriyama K and Tateishi R: Development of postoperative intrathoracic chemothermotherapy for lung cancer with objective of improving local cure. Cancer: In Press.Google Scholar
  9. 9.
    Lee CKK, Song CW, Rhee JG and Levitt SH: Clinical experience with Thermotron RF–8 capacitive heating for bulky tumors: University of Minnesota Experience. Radiologic Clinic of North America 27: 543–558, 1989.Google Scholar
  10. 10.
    Matsuda T, Sugiyama A and Nakada Y: Studies of radiofrequency hyperthermia (First report). Fundamental studies of Thermotron hyperthermia. J Japn Soc Cancer Ther 18: 1904–1914, 1983.CrossRefGoogle Scholar
  11. 11.
    Meyer JL, Kapp DS, Fessenden P and Hahn GH: Hyperthermic Oncology: Current biology, physics and clinical results. Pharmac Ther 42: 251–288, 1989.CrossRefGoogle Scholar
  12. 12.
    Nakajima K and Hisazumi H: An experimental study of temperature distribution in prostatic cancer at 8 MHz RF heating using agar phantom. Japn J Hyperthermic Oncol 1: 131–137, 1985.Google Scholar
  13. 13.
    Nakajima K, Hisazumi H, Misaki T, Naito K, Uchibayashi T, Koshida K, Ueki 0, Kobashi K, Yamamoto H, Fuse H, Takashima M, Nitta M, Asari T and Saito Y: A combined treatment of 8MHz radiofrequency hyperthermia and THP-adriamycin or irradiation for bladder carcinoma. Japn J Hyperthermic Oncol 2: 383–388, 1986.Google Scholar
  14. 14.
    Onoyama Y: Studies of the combined use of hypoxic cell sensitizers and hyperthermia with radiation in human cancer therapy. IAEA–TECDOC–492, Vienna, 1989.Google Scholar
  15. 15.
    Overgaard J: The current and potential role of hyperthermia in radiotherapy. Int J Radiat Oncol Biol Phys 16: 535–549, 1989.PubMedCrossRefGoogle Scholar
  16. 16.
    Song CW, Rhee JG, Lee CKK and Levitt SH: Capacitive heating of phantom and human tumors with an 8 MHz radiofrequency applicator (Thermotron RF–8). Int J Radiat Oncol Biol Phys 12: 365–372, 1986.PubMedCrossRefGoogle Scholar
  17. 17.
    Yanagawa S, Sone Y, Doi H and Yamamoto G: A new procedure for the prevention of surface overheating in deep hyperthermia using RF capacitive heating equipment. Japn J Hyperthermic Oncol 1: 187–191.Google Scholar
  18. 18.
    Yoshikawa T, Oyamada H, Ichikawa H, Naito Y, Ueda S, Tainaka K, Itani K, Seto 0, Sugino S and Kondo M: Antitumor effect and indication of chemoembolization using degradable starch microspheres and regional hyperthermia in patients with hepatocellular carcinoma. J Japn Soc Cancer Ther 24: 786–792, 1989.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • U. Raymond
    • 1
    • 2
  • Tsutomu Sugahara
    • 3
  1. 1.Rex Cancer CenterRaleighUSA
  2. 2.East Carolina School of MedicineGreenvilleUSA
  3. 3.Health Research FoundationKyoto 602Japan

Personalised recommendations