Responses of Immune System to Hyperthermia

  • Z. L. Olkowski
  • W. W. Jedrzejczak
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 267)


The evidence of time dependent, heat induced impairment of immune functions is unequivocal from in vitro studies. While earlier investigations at moderately elevated temperatures led researchers to postulate that in the clinical set-up hyperthermia might in fact stimulate the immune system. the growing number of studies at more relevant temperatures provide no support for this concept. For review of the temperatures see Skeen et al, 1986. Since the importance of immune reactions in tumor control after hyperthermia has been firmly established in immunodeficient mice (Alfieri et al, 1981) the relevance of in vitro data to the situation in inpatients undergoing hyperthermia remains to be determined. The clinical situation is obviously more complex and it has proven in the past to be difficult to correlate patients immunological parameters with clinical outcome in cancer patients.


Tumor Control Tumor Infiltrate Lymphocyte Immunodeficient Mouse Specific Growth Factor Adoptive Immunotherapy 
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  1. 1.
    Alfiere, A.A., Hahn, E.W., and Kim, J.H. Role of cell mediated immunity in tumor eradication by hyperthermia.Cancer Res. 41, 1301, 1981Google Scholar
  2. 2.
    Anghileri, L.J. - Role of tumor cell membrane in hyperthermia. In “Hyperthermia in Cancer Treatment.” Eds. L.J. Anghileri and J. Robert Vol. 1, 1, 1986, CRC Press, Boca Raton, Fla.Google Scholar
  3. 3.
    Skeen, M.J., McLaren, J.R., and Olkowski, Z.L.Influences of Hyperthermia on Immunological Functions. Ibid., Vol. I, 94, 1986Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Z. L. Olkowski
    • 1
  • W. W. Jedrzejczak
    • 2
  1. 1.Emory University Medical SchoolAtlantaUSA
  2. 2.Education Medical CenterCSK WAMWarsawPoland

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