Immunotherapeutical Strategies in Cancer Patients

  • Irene Munno
  • Claudio De Simone
  • Vito Covelli
  • Emilio Jirillo
  • Salvatore Antonaci
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 267)


Individuals bearing tumors belong to the category of immunocompromised subjects. In fact, these patients exhibit multiple deficits of their immune responsiveness either in terms of acquired immune response or in terms of phagocytic functions1. The above immune dysfunctions may depend on several factors2 such as:
  1. i.

    Suppressive factors released by the same neoplasia;

  2. ii.

    A primary condition of immune alteration in a given subject which may be responsible for the development of the neoplasia. In this respect, individuals affected by congential immunodeficiencies or secondary immune deficits (e.g. transplanted patients or uremic subjects) undergo cancer with higher frequency than patients who had no clear evidence of immune alterations before the discovery of cancer;

  3. iii.

    Chemotherapy and radiotherapy represent an additional cause of immune suppression in neoplastic patients.



Natural Killer Cell Lactic Acid Bacterium Bacillus Calmette Guerin Acetic Acid Bacterium Lepromatous Leprosy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Irene Munno
    • 1
  • Claudio De Simone
    • 2
  • Vito Covelli
    • 3
  • Emilio Jirillo
    • 1
  • Salvatore Antonaci
    • 4
  1. 1.ImmunologiaUniversity of BariBariItaly
  2. 2.Malattie InfettiveUniversità dell’ Aquila degli AbruzziL’ AquilaItaly
  3. 3.Neuro-anatomia ClinicaUniversity of BariBariItaly
  4. 4.Fisiopatologia Medica IUniversity of BariBariItaly

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