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Micronuclei Assay — A Predictive Variable for Tumor Response to Treatment

  • Homayoon Shidnia
  • William Crabtree
  • Ned Hornback
  • Peter Young
  • Mary Hartson
  • Rong-Nian Shen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 267)

Abstract

Our preliminary data indicate that the formation of micronuclei (MN) in treated tumor cells is a predictive variable for tumor response to treatment. In a pilot study involving four patients who received both radiation therapy and hyperthermia, fine needle aspirate (FNA) samples were taken and analyzed before therapy, and after each 1000 centigray (cGy) up to 3000 cGy. The results indicate a correlation between increasing formation of micronuclei and decreasing tumor volume. All of the patients in this Study have had their tumors under control for at least one year.

Our preliminary data demonstrated that a high level of micronuclei in tumor cells correlates with favorable response of the tumor to treatment with radiation and heat. The assay is easy to perform and FNA biopsy could be done in the clinic with minimal discomfort to the patient.

Keywords

Fibrous Histiocytoma Micronucleus Assay Fine Needle Aspirate Micronucleus Formation Minimal Discomfort 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Homayoon Shidnia
    • 1
  • William Crabtree
    • 1
  • Ned Hornback
    • 1
  • Peter Young
    • 1
  • Mary Hartson
    • 1
  • Rong-Nian Shen
    • 1
  1. 1.Indiana University School of MedicineIndianapolisUSA

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