Enhancing Thermoradiotherapy Efficacy by Hyperglycemia
The tumorcidal effect of hyperthermia (HT) and especially of combined use of HT and radiation-thermoradiotherapy (TRT) may be substantially increased byinduced hyperglycemia (HG). In this respect we have shown: (1) that the proper scheduling of TRT with HG is very important and (2) that the therpeutic effect is highly dependent on HG-induced changes in certain physiological processes, such as inhibition of blood flow, increasing hypoxia and anaerobic glycolysis and decreasing pH in tumors. The first results of clinical use of HG have been also received. A search for the most efficient scheme of TRT with HG (Fig.1) was based on the following principles: (1) J.Overgaard (1982) and some others demonstrated the advantages of tumor heating several hours after irradiation; (2) according to our studies (S.P.Yarmonenko et al., 1981)the induction of HG, especially after irradiation, selectively increases the antitumor effect of irradiation; (3) M. von Ardenne, P.G. Reitnauer (1980) and many others demonstrated that the tumoricidal effect of HT was increased under hyperglycemic conditions due to a decreased pH and blood flow. Taking into consideration all these data we proposed that the following sequence of treatment should be most effective: irradiation followed by HG and then by HT (the last line on Fig. 1).
KeywordsEsophageal Carcinoma Anaerobic Glycolysis Tumor Growth Delay Lung Squamous Cell Carcinoma Glycolytic Activity
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