Local Microwave Hyperthermia and Benign Prostatic Hyperplasia Induced Bladder Outlet Obstruction

  • Patrizio Rigatti
  • Giorgio Guzzoni
  • Francesco Montorsi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 267)


Hyperthermia (HT) has been used as a treatment for cancer since last century, both alone or combined with chemotherapy and radiotherapy. The rationale supporting the application of heat in cancer therapy is based on the following data: 1.) HT increases tumor sensitivity to radiation and it can be cytotoxic itself 2.) HT increases the rate of neoplastic necrosis induced by chemotherapy 3.) hypoxia cells are sensitive to HT while are resistant to radiations 4.) solid tumors are heat reservoirs due to poor blood supply 5.) tumors previously irradiated can be submitted to HT with no additional damage to normal tissue 6.) heat inhibits the repair of radiation induced damage to DNA 7.) neoplastic cells are more sensitive to heat (42–44 °C) than normal cells. This experimental and clinical evidence contributed to the progressive broadening in the use of HT. In 1982 Yerushalmi and associates (1) reported the first series of prostate cancer patients submitted to selective prostatic HT. Since then, several authors have reported experience with local HT for prostatic diseases (2.3). This study reports our series of 100 benign prostatic hypertrophy (BPH) submitted to local prostatic HT and evaluated at the six month follow-up date by clinical, histological and ultrastructural studies.


Benign Prostatic Hyperplasia Indwell Catheter Benign Prostatic Hypertrophy Cyproterone Acetate Heat Reservoir 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Patrizio Rigatti
    • 1
  • Giorgio Guzzoni
    • 1
  • Francesco Montorsi
    • 1
  1. 1.Department of UrologyIstituto San Raffaele MilanItaly

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