Whole Body Hyperthermia Experience in Breast Cancer at American International Hospital
One hundred thirty nine patients with metastatic breast cancer were seen at American International Hospital during the years 1982–86. Forty two evaluable patients received whole body hyperthermia (WBH) via the the heated water blanket technique of Barlogie et all and of Larkin et al2 with chemotherapy. Our 1985 research protocol outlined a plan of initial chemotherapy for up to two months, with WBH added in poor responders. We attempted to achieve a core body temperatures of 42.2° C for two hours. Chemotherapy began 18 hours after completion of WBH. This was done to utilize WBH under optimum conditions, and to gain experience with a wide range of chemotherapy drugs, each given in combinations and doses chosen to be optimum for patient care independant of WBH. These studies were primarily intended to evaluate the safety of both forms of therapy given sequentially.
KeywordsMetastatic Breast Cancer Poor Responder Visceral Metastasis Initial Chemotherapy Prior Chemotherapy Regimen
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