Local Hyperthermia for Superficial and Moderately Deep Tumors--Factors Affecting Response

  • Haim I. Bicher
  • Ralph S. Wolfstein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 267)

Abstract

Many reports in the peer review medical literature on the clinical application of hyperthermia over more than a decade have contributed to recognition of its safety and efficacy, with a synergistic effect in combination with radiation and/ or chemotherapy. (1–36)

Keywords

Toxicity Microwave Adenocarcinoma Acidity Fractionation 

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References

  1. 1).
    Arcangeli G, Barni E, Cividalli A, et al: Effectiveness of microwave hyperthermia combined with ionizing radiation;Clinical results on neck node metastases Int J Radiat Oncol Biol Phys 6: 143–148, 1980PubMedCrossRefGoogle Scholar
  2. 2).
    Arcangeli G, Cividalli A, Nervi C, et al: Tumor control and therapeutic gain with different schedules of combined radiotherapy and local external hyperthermia in human cancer. Int J Radiat Oncol Biol Phys 9: 1125–1134, 1983PubMedCrossRefGoogle Scholar
  3. 3).
    Bicher H I, Sandhu T: Results of a phase I/II clinical trial of fractionated hyperthermia in combination with low dose ionizing radiation. In Bicher H I, Bruley D (Eds): Hyperthermia. New York, Plenum Press 1982 pp 87–89Google Scholar
  4. 4).
    Bicher H.I, Sandhu T, Hetzel F: Hyperthermia and radiation in combination: A clinical fractionation regime. Int J Radiat Oncol Biol Phys 6: 867–870, 1980PubMedCrossRefGoogle Scholar
  5. 5).
    Hornback NB, Shupe RE, Homayon S, et al: Preliminary clinical results of combined 433 MHz microwave therapy and radiation therapy on patients with advanced cancer. Cancer 40: 2854–2863, 1977PubMedCrossRefGoogle Scholar
  6. 6).
    Hornback NB, Shupe RE, Shidnia H, et al: Radiation and microwave therapy in the treatment of advanced cancer. Radiology 130: 459–464, 1979PubMedGoogle Scholar
  7. 7).
    Johnson R, Sandhu T, Hetzel F, et al: A pilot study to investigate the therapeutic ratio of hyperthermia 41.5–42.0 C and radiation. Int J Radiat Oncol Biol Phys 5: 947–954 1979Google Scholar
  8. 8).
    Kim J, Hahn GM, Benjamin F: Treatment of superficial cancer by combination hyperthermia and radiation therapy. Clin Bull 9: 13–16, 1979PubMedGoogle Scholar
  9. 9).
    Manning M, Cetas T, Miller R, et al: Clinical hyperthermia: Results of a phase I clinical trial employing hyperthermia alone or in combination with external beam or intersitial radiotherapy. Cancer 49: 205–216, 1982PubMedCrossRefGoogle Scholar
  10. 10).
    Oleson J, Manning M, Heusinkveld R: Hyperthermia by magnetic induction.II. Clinical experience with concentric electrodes. Int J Radiat Oncol Biol Phys 9: 549–556, 1983PubMedCrossRefGoogle Scholar
  11. 11).
    Oleson J, Manning M, Sim D, et al: A review of the University of Arizona human clinical hyperthermia. experience. Front Radiat Ther Onc 18: 136–143, 1984Google Scholar
  12. 12).
    Sapozink M, Gibbs F, Gates K, et al: RegionalGoogle Scholar
  13. hyperthermia in the treatment of clinically advanced deep seated malignancy: Results of a study employing an annular array applicator. Int J Radiat Oncol Biol Phys 10: 775–786, 1984CrossRefGoogle Scholar
  14. 13).
    Sapozink M, Gibbs F, Thomson J, et al: A comparison of deep regional hyperthermia from an annular array and a concentric coil in the same patients. Int J Radiat Oncol Biol Phys. 11: 179–190, 1985PubMedCrossRefGoogle Scholar
  15. 14).
    Scott R, Johnson R, Kowal H, et al: Hyperthermia in combination with radiotherapy; a review of five years experience in the treatment of superficial tumors. Int J Radiat Oncol Biol Phys 9: 1327–1333, 1983PubMedCrossRefGoogle Scholar
  16. 15).
    Scott R. Johnson R, Story K, et al: Local hyperthermia in combination with definitive radiotherapy: increased tumor clearance, reduced recurrence rate in extended follow up. Int J Radiat Oncol Biol Phys 10: 2119–2123, 1984PubMedCrossRefGoogle Scholar
  17. 16).
    Storm K, Silberman A, Ramming K, et al: Clinical thermochemotherapy: A controlled trial in advanced cancer patients. Cancer 53: 863–868, 1984PubMedCrossRefGoogle Scholar
  18. 17).
    U R, NoellK, Woodward K, et al: Microwave induced local hyperthermia in combination with radiotherapy of human malignant tumors. Cancer 45: 638–646, 1980CrossRefGoogle Scholar
  19. 18).
    Fazekas JT, Nerlinger B S Localized hyperthermia adjuvant to irradiation in superficial recurrent carcinomas: A preliminary report on 46 patients. Int J Radiat Oncol Biol Phys 7: 1457–1463, 1981PubMedCrossRefGoogle Scholar
  20. 19).
    Dunlop P R C, Hand J W, Dickinson R J, et al: Combined radiation and hyperthermia in clinical practice. Int J Hyperthermia 2: 39–50, 1986PubMedGoogle Scholar
  21. 20).
    Luk K H, Francis M E, Perez C A, et al: Combined radiation and hyperthermia: Comparison of two treatment schedules based on data from a registry established by the radiation therapy oncology group (RTOG). Int J Radiat Oncol Biol Phys 10: 801.-809, 1984Google Scholar
  22. 21).
    Field S B, Bleehen N M: Hyperthermia in the treatment of Cancer. Cancer treatment reviews 6: 63–94, 1979PubMedCrossRefGoogle Scholar
  23. 22).
    Marmor J B, Hahn G M: Combined radiation and hyperthermia in superficial human tumors. Cancer 46: 1986–1991, 1980Google Scholar
  24. 23).
    Arcangeli G, Nervi C: The lack of clinical evidence of tumor thermotolerance after some schedules of combined heat (HT) and radiation (RT). In Overgaard J (ed): Hyperthermia Oncology 1984 Vol. 1. Taylor and Francis, London and Philadelphia, 1984, pp 231–235Google Scholar
  25. 24).
    Corry P M, Barlogie B, Tilchen E J, et al: Ultrasound-induced hyperthermia for treatment of human superficial tumors. Int J Radiat Oncol Biol Phys 8: 1225–1229, 1982PubMedGoogle Scholar
  26. 25).
    Saoozink M D, Gibbs F A, Egger M J, et al: Abdominal regional hyperthermia with an annular phased array. J Clin Oncol 4: 775–783, 1986Google Scholar
  27. 26).
    Oleson, J R, Sim D H, Conrad J, et al: Results of a phase I regional device evaluation: Microwave annular array versus radiofrequency induction coil. Int J Hyperthermia 2: 327–336, 1986PubMedCrossRefGoogle Scholar
  28. 27).
    Arcangeli G, Benassi M, Cividalli A, et al:Radiotherapy and hyperthermia. Analysis of clinical results and identification of prognostic variables. Cancer 60: 950–956, 1987PubMedCrossRefGoogle Scholar
  29. 28).
    Hiraoka M, Jo S„ Akuta K et al: Radiofreauency capacitive hyperthermia for deep seated tumors. II. Effects of thermoradiotherapy. Cancer 60: 128–135, 1987PubMedCrossRefGoogle Scholar
  30. 29).
    Falk R E, Moffat. F L, Lawler M, et al: Combination therapy for resectable and unresectable adenocarcinoma of the pancreas. Cancer 57: 685–688, 1986PubMedCrossRefGoogle Scholar
  31. 30).
    Moffat F L, Gilas T, Calhoun K, et al: Further experience with regional radiofrequency hyperthermia and cytotoxic chemotherapy for unresectable hepatic neoplasia. Cancer 55: 1291–1295, 1985PubMedCrossRefGoogle Scholar
  32. 31).
    Bicher H I, Wolfstein. R S, Lewinsky B S, et al:Microwave hyperthermia as an adjunct to radiation therapy: summary experience of 256 multifraction treatment cases. Int J Radiat Oncol Biol Phys 12: 1667–1671, 1986PubMedCrossRefGoogle Scholar
  33. 32).
    Hahn G M: Hyperthermia to enhance drug delivery. In Rational Basis for chemotherapy, Alan R. Liss, N Y, 1983, pp 42. 7–436Google Scholar
  34. 33).
    Hahn G M: Interaction of hyperthermia and drugs:Treatments and probes. Natl Cancer Inst Monogr 61: 317–323, 1982PubMedGoogle Scholar
  35. 34).
    Engelhardt R: Hyperthermia and drugs. Recent Results Cancer Res 104: 136–203, 1987PubMedCrossRefGoogle Scholar
  36. 35).
    Storm F K, Scanlon E F, Baker H W, et al: Tumor stabilization after hyperthermia: an important criterion of response to thermal therapy. J Sur Oncol 34: 143–149, 1987CrossRefGoogle Scholar
  37. 36).
    Bicher H I, Wolfstein R S: Local hyperthermia for deep tumors experience with three techniques. In J Microwave Power, symposium summaries: 1986,po 103–104Google Scholar
  38. 37).
    Bicher H I, Hetzel F: Effects of hyperthermia on normal and tumor microenvironment. Radiology 137: 523–530. 980Google Scholar
  39. 38).
    Emami B, Nussbaum G H, TenHaken R K, et al: Physiological effects of hyperthermia: response of capillary blood flow and structure to local tumor heating. Radiology 137: 805–809, 1980PubMedGoogle Scholar
  40. 39).
    Bicher H I, Mitagvaria N P: Circulatory response of malignant tumors during hyperthermia. Microvascular Res 21: 19–26, 1981CrossRefGoogle Scholar
  41. 40).
    Song C W, Kang M S, Rhee J G, et al: The effect of hyperthermia on vascular function, pH and cell survival. Radiology 137: 795–803, 1980PubMedGoogle Scholar
  42. 41).
    Li G C, Evans R G, Hahn G M: Modification and inhibition of repair of potentially lethal x-ray damage by hyperthermia. Rad Res 67: 491–501, 1976CrossRefGoogle Scholar
  43. 42).
    Dewhirst M W, Ozimek E J, Gross J, et al: Will hyperthermia conquer the elusive hypoxic cell? Implications of heat effects on tumor and normal tissue microcirculation. Radiology 137: 811–817. 1980PubMedGoogle Scholar
  44. 43).
    Urano M, Maher J, Kahn J, et al: Studies on fractionated hyperthermia in experimental animal systems III. uneven daily doses. Int J Radiat Oncol Biol Phys 9: 717 72–1983Google Scholar
  45. 44).
    Urano M, Kahn J: Differential Kinetics of thermal resistance (thermotoleranCe) between murine normal and tumor tissue. Int J Radiat Oncol Biol Rhys 12: 89–93, 1986CrossRefGoogle Scholar
  46. 45).
    Mivechi N F, Hofer K E: Evidence for separate modes of action in thermal radiosenitization and direct thermal cell death. Cancer 51: 38–43, 1983PubMedCrossRefGoogle Scholar
  47. 46).
    Bicher H I, Mitagvaria N P: Changes in tumor tissue oxygenation during microwave hyperthermia-clinical relevance. In Overgaard J (ed): Hyperthermia Oncology 1984 1: Taylor & Francis, London and Philadelphia, 1984, pp 169–172Google Scholar
  48. 47).
    Vaupel P, Kallinowski F: Physiological effects of hyperthermia. Recent Results Cancer Res 104: 71–109, 1987PubMedCrossRefGoogle Scholar
  49. 48).
    Corry P M, Robinson S, Getz B S: Hyperthermia effecte on DNA repair mechanisms. Radiology 123: 475–482, 1987Google Scholar
  50. 49).
    Bicher H I, Moore D, Wolfstein R S: Air-cooled 300MHz applicators used in a parallel opposed phased system(POPAS). Int J Radiat Oncol Biol Phys 11: S1:217, 1985 (abst)Google Scholar
  51. 50).
    Marmor J B: Interactions of hyperthermia and chemotherapy in animals Cancer Res 39: 2269–2276, 1979Google Scholar
  52. 51).
    Hahn G M: Potential for therapy of drugs and hyperthermia. Cancer Res 39: 2. 264–2268, 1979Google Scholar
  53. 52).
    Kapp D S: Site and disease selection for hyperthermia clinical trials. Int J Hyperthermia 2: 139–156, 1986PubMedCrossRefGoogle Scholar
  54. 53).
    Goldin E M, Leeper D B: The effect of reduced pH on the induction of thermotolerance. Radiology 141: 505–508, 1981PubMedGoogle Scholar
  55. 54).
    Falk R E, Newhook L, Moffat FL, et al:Thermochemotherapy for unresectable hepatic cancer. Recent Results Cancer Res. 100: 315–32. 0, 1986Google Scholar
  56. 55).
    Hornback N B, Shupe RE, Shidnia H, et al: Advanced stage III8 Cancer of the cervix treatment by hyperthermia and radiation. Gyn Oncol 23: 160–167, 1986CrossRefGoogle Scholar
  57. 56).
    Streffer C, Van Beuningen D, Marbach J:Thermotolerance: A barrier for the use of hyperthermia in tumor therapy ? Int J Radiat Oncol Phys 8:109 (abst.),1982Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Haim I. Bicher
    • 1
  • Ralph S. Wolfstein
    • 1
  1. 1.Valley Cancer InstitutePanorama City Los AngelesUSA

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