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Procedures for Improving Therapeutic Gain

  • S. Osinsky
  • L. Bubnovskaja
  • A. Gusev
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 267)

Abstract

A number of studies (Bhuyan et al., 1977; Freeman et al., 1980; Kim et al., 1980; Haveman, Hahn, 1981) have determined that the best conditions to realize a maximum antitumor hyperthermia (HT) effect are the following: low pH, hypoxia, slow blood flow, deficiency of nutrients and energy and increase in cell numbers in the S-phase of a cell cycle. It was shown that tumor tissue pH is selectively decreased under induced hyperglycemia (IHG) (see the reviews by Wike-Hooley et al., 1984; Zavrid et al., 1987).According to this phenomenon von Ardenne (1966, 1972) has suggested the use of IHG for enhancement of thermosensitivity.

Keywords

Glucose Solution Glucose Infusion Blood Flow Rate Glycemia Level Tumor Acidification 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • S. Osinsky
    • 1
  • L. Bubnovskaja
    • 1
  • A. Gusev
    • 1
  1. 1.R.E. Kavetsky Institute for Oncology ProblemsKiev-022USSR

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