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The Role of Hyperthermic Perfusion in the Treatment of Tumors of the Extremities

  • F. Di Filippo
  • S. Carlini
  • F. Cavaliere
  • D. Giannarelli
  • L. Cavallero
  • F. Moscarelli
  • L. Aloe
  • R. Cavaliere
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 267)

Abstract

Approximately 60% of all soft tissue and osteogenic sarcomas and 50% of all melanomas arise in the extremities. Treatment of these tumors has traditionally been limited to local surgical procedures, often resulting in a non-functioning limb or amputation, particularly in the case of sarcoma and in a local recurrence rate Primarily related to the biological tumor aggressiveness. A higi incidence of micrometastatic nodules has been found in most high-grade sarcomas and in high-risk melanomas in the form of “skip” or “in transit” metastases. This suggests that these tumors cannot be managed as locally confined neoplasms, being a regional disease “ab initio” and requiring loco-regional treatment.

Keywords

Osteogenic Sarcoma Soft Tissue Sarcoma Conservative Surgery Antineoplastic Drug Osteogenic Sarcoma Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • F. Di Filippo
    • 1
  • S. Carlini
    • 1
  • F. Cavaliere
    • 1
  • D. Giannarelli
    • 1
  • L. Cavallero
    • 1
  • F. Moscarelli
    • 1
  • L. Aloe
    • 1
  • R. Cavaliere
    • 1
  1. 1.Department of SurgeryRegina Elena National Cancer InstituteRomeItaly

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