Abstract
Intraperitoneal (IP) cisplatin-based chemotherapy provides prolonged disease-free survival in some women with residual peritoneal ovarian cancer following systemic chemotherapy. This review presents several considerations which support the combined use of IP carboplatin and whole body hyperthermia in this patient population. This novel treatment approach is predicated on projected advantages which relate to improved therapeutic index.
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Andrews, P.A., Velury, S., Mann, S.C., and Howell, S.B. cis-Diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells. Cancer Res. 48: 68–73, 1988.
Barlogie, B., Corry, P.M., and Drewinko, B. In vitro thermochemotherapy of human colon cancer cells with cis-dichlorodiammineplatinum(II) and mitomycin C. Cancer Res. 40:1165–1168, 1980.
Calvert, A.H., Harland, S.J., Newell, D.R., Siddik, Z.H., Jones, A.C., McElwain, P.G., Raju, S., Wiltshaw, E., Smith, I.E., Baker, J.M., Peckham, M.J., and Harrap, K.R. Early clinical studies with cisdiammine-1,1-cyclobutane dicarboxylate platinum II. Cancer Chemother. Pharmacol. 9: 140–147, 1982.
Cohen, J.D., and Robins, H.I. Hyperthermie enhancement of cisdiammine-1,1-cyclobutane dicarboxylate platinum(II) cytotoxicity in human leukemia cells in vitro. Cancer Res. 47: 4335–4337, 1987.
Cohen, J.D., Robins, H.I., and Schmitt, C.L. Interactions of hyperthermia with carboplatin, cisplatin, and etoposide in human leukemia cells in vitro. Cancer Letters, in press.
Curt, G.A., Grygiel, J.J., Corden, B.J., Ozols, R.F., Weiss, R.B., Tell, D.T., Myers, C.E., and Collins, J.M. A Phase I and pharmacokinetic study of diamminecyclobutanedicarboxylatoplatinum (NSC 241240). Cancer Res. 43: 4470–4473, 1983.
Decker, D.G., Fleming, T.R., Malkasian, G.D. et al. Cyclophosphamide plus cisplatinum in combination: Treatment program for stage III or IV ovarian carcinoma. Obstetrics and Gynecology 60: 481–487, 1982.
Dedrick, R.L., Myers, C.E., Bungay, P.M., and DeVita, V.T. Jr. Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer. Cancer Treat. Rep. 62: 1–11, 1978.
Eichholtz-Wirth, H., and Hietel, B. The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro. Brit. J. Cancer 54: 239–243, 1986.
Fisher, G., and Hahn, G.M. Enhancement of cis-platinum(II)diarrminedichloride cytotoxicity by hyperthermia. National Cancer Institute Monographs 61: 255–257, 1982.
Gerad, H., Egorin, M.J., Whitacre, M., Van Echo, D.A., and Aisner, J. Renal failure and platinum pharmacokinetics in three patients treated with cis-diamminedichloroplatinum(II) and whole body hyperthermia. Cancer Chemotherapy and Pharmacology 11: 162–166, 1983.
Howell, S.B., Pfeifle, C.L., Wung, W.E., Olshen, R.A., Lucas, W.E., Yon, J.L., and Green, M. Intraperitoneal cisplatin with systemic thiosulfate protection. Ann. Int. Med. 97: 845–851, 1982.
Howell, S.B., Zimm, S., Markman, M., Abramson, I.S., Cleary, S., Lucas, W.E., and Weiss, R.J. Long-term survival of advanced refractory ovarian carcinoma patients with small-volume disease treated with intraperitoneal chemotherapy. J. Clin. Oncol. 5: 1607–1612, 1987.
Hugander, A., Robins, H.I., Martin, P., and Schmitt, C. Temperature distribution during radiant heat whole-body hyperthermia: experimental studies in the dog. Int. J. Hypertherm. 3: 199–208, 1987.
Joss, R.A., Kaplan, S., Goldhirsch, A., Sessa, C., Brunner, K.W., and Cavalli, F. A Phase I trial of cis-diammine-1,1-cyclobutane dicarboxylate platinum II (Carboplatin, CBDCA, JM-8) with a single dose every five-week schedule. Invest. New Drugs 2: 297–304, 1984.
Koeller, J.M., Trump, D.L., Tutsch, K.D., Earhart, R.H., Davis, T.E., Tormey, D.C. Phase I clinical trial and pharmacokinetics of carboplatin (NSC 241240) by single monthly 30-minute infusion. Cancer 57: 222–225, 1986.
Kraker, A.J., and Moore, C.W. Accumulation of cis-diamminedichloroplatinum(II) and platinum analogues by platinum-resistant murine leukemia cells in vitro. Cancer Res. 48: 9–13, 1988.
Lambert, H.E., and Berry, R.J. High dose cisplatin compared with high dose cyclophosphamide in the management of advanced epithelial ovarian cancer (FIGO stages III and IV): Report from the North Thames Cooperative Group. Brit. Med. J. 290: 889–893, 1985.
Levin, L., and Hryniuk, W.M. Dose intensity analysis of chemotherapy regimens in ovarian carcinoma. J. Clin. Oncol. 5: 756–767, 1987.
Markman, M., Cleary, S., and Howells, S.B. Nephrotoxicity of high-dose intracavitary cisplatin with intravenous thiosulfate protection. Eur. J. Clin. Oncol. 21: 1015–1018, 1985.
McVie, J.G., Dikhoff, T., Van der Heide, J., et al. Tissue concentra- tion of platinum after intraperitoneal cisplatin administration in patients. Abstract, Proc. Amer. Assoc. Cancer Res. 26: 162, 1985.
McVie, J.G., ten Bokkel Huinink, W.W., Dubbelman, R., Franklin, H., van der Vijgh, W., and Klein, I. Phase I study and pharmacokinetics of intraperitoneal carboplatin. Cancer Treat. Rev. 12: 35–41, 1985.
Meyn, R.E., Corry, P.M., Fletcher, S.E., and Demetriades, M. Thermal enhancement of DNA damage in mammalian cells treated with cis-diamminedichloroplatinum (II). Cancer Res. 40: 1136–1139, 1980.
Myers, C.E. The use of intraperitoneal chemotherapy in the treatment of ovarian cancer. Sem. Oncol. 11: 275–284, 1984.
Myers, C.E., and Collins, J.M. Pharmacology of intraperitoneal chemotherapy. Cancer Invest. 1: 395–407, 1983.
Omura, G., Blessing, J.A., Ehrlich, C.E., et al. A randomized trial of cyclophosphamide and doxorubicin with or without cisplatin in advanced ovarian carcinoma. Cancer 57: 1725–1730, 1986.
Ozols, R.F., Behrens, B.C., Ostchega, Y., and Young, R.C. High dose cisplatin and high dose carboplatin in refractory ovarian cancer. Cancer Treat. Rep. 12: 59–65, 1985.
Riviere, J.E., Page, R.L., Dewhirst, M.W., Tyczkowska, K., and Thrall, D.E. Effect of hyperthermia on cisplatin pharmacokinetics in normal dogs. Int. J. Hypertherm. 2: 351–358, 1986.
Robins, H.I., Dennis, W.H., Neville, A.J., Shecterle, L.M., Martin, P.A., Grossman, J., Davis, T.E., Neville, S.R., Gillis, W.K., and Rusy, B.F. A nontoxic system for 41.8°C whole body hyperthermia: Results of a Phase I study using a radiant heat device. Cancer Res. 45: 3937–3944, 1985.
ten Bokkel Huinink, W.W., Dubbelman, R., Aartsen, E., Franklin, H., and McVie, J.G. Experimental and clinical results with intraperitoneal cisplatin. Sem. Oncol. 12: 43–46, 1985.
Thrall, D.E., Page, R.L., Dewhirst, M.W., Meyer, R.E., Hoopes, P.J., and Kornegay, J.N. Temperature measurements in normal and tumor tissue of dogs undergoing whole body hyperthermia. Cancer Res. 46: 6229–6235, 1986.
Wallner, K.E., DeGregorio, M.W., and Li, G.C. Hyperthermie potentiation of cis-diamminedichloroplatinum(II) cytotoxicity in Chinese hamster ovary cells resistant to the drug. Cancer Res. 46: 6242–6245, 1986.
Wiltshaw, E., Evans, B., and Harland, S. Phase III randomised trial of cisplatin versus JM8 (carboplatin) in 112 ovarian cancer patients, stages III and IV. Abstract, Proc. Amer. Soc. Clin. Oncol. 4: 121, 1985.
Wondergem, J., Bulger, R.E., Strebel, F.R., Newman, R.A., Travis, E.L., Stephens, L.C., and Bull, J.M.C. Effect of cis-diamminedichloroplatinum(II) combined with whole body hyperthermia on renal injury. Cancer Res. 48: 440–446, 1988.
Zakris, E.L., Dewhirst, M.W., Riviere, J.E., Hoopes, P.J., Page, R.L., and Oleson, J.R. Pharmacokineties and toxicity of intraperitoneal cisplatin combined with regional hyperthermia. J. Clin. Oncol. 5: 1613 1620, 1987.
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© 1990 Plenum Press, New York
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Cohen, J.D., Robins, H.I. (1990). Whole Body Hyperthermia and Intraperitoneal Carboplatin in Residual Ovarian Cancer. In: Bicher, H.I., McLaren, J.R., Pigliucci, G.M. (eds) Consensus on Hyperthermia for the 1990s. Advances in Experimental Medicine and Biology, vol 267. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5766-7_18
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DOI: https://doi.org/10.1007/978-1-4684-5766-7_18
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