Extracorporeally Induced Total-Body Hyperthermia for Disseminated Cancer

  • Shigemasa Koga
  • Michio Maeta
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 267)


Although the mechanisms of the anticancer effects of hyperthermia have remained obscure, it is now generally accepted that the heating temperature must be at least 41.0°C or greater to achieve cancer regression. Clinically applied thermochemotherapy can be divided into local and total-body hyperthermia (TBHT). Local hyperthermia has been primarily used in the treatment of superficial and localized malignant tumors. Because advanced cancer infiltrates neighboring organs and is often metastatic to other distant organs, TBHT appears to be a reasonable and a promising approach. Although various methods for TBHT have been reported, we have been performed TBHT using an extracorporeal circuit modified from the original of Parks et al.2 In this chapter, we describe the clinical effect of TBHT combined with anticancer chemotherapy and some problems in this area.


Antitumor Effect Advanced Cancer Patient Extracorporeal Circuit Local Hyperthermia Anticancer Chemotherapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Shigemasa Koga
    • 1
  • Michio Maeta
    • 1
  1. 1.First Department of SurgeryTottori University School of MedicineYonagoJapan

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