Conductive, Interstitial Hyperthermia: A New Modality for Treatment of Intracranial Tumors

  • J. Alexander Marchosky
  • Charles F. Babbs
  • Christopher J. Moran
  • Neal E. Fearnot
  • John A. DeFord
  • Deborah M. Welsh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 267)


Malignant brain tumors comprise a devastating class of diseases with an overall dismal prognosis. The incidence of primary malignant gliomas, the most common category of primary intracranial tumors, is 12,000 to 15,000 patients per year in the United States.1,2 Metastatic brain tumors are reported in an additional 100,000 patients per year.3,4 Whereas the survival of patients with metastatic intracranial tumors is often determined by widespread systemic disease, in primary intracranial malignancies local recurrence represents the major source of failure. Despite aggressive cytoreductive surgery, radiation therapy, and chemotherapy, the clinical outcome is generally grim. Salcman (1980) in a review of 1561 glioblastoma cases treated with maximal resection, with or without the addition of radiation or radiation plus chemotherapy, found a two-year survival of 10%.5 Walker (1978) in a study of 222 patients with anaplastic gliomas found 1% survival at 24 months with surgery and radiation therapy, and 5% survival at 24 months with surgery, BCNU and radiation.6 Multiple combinations of modalities and different approaches have been explored quite extensively by many investigators. Even studies resorting to extreme approaches using high doses of radiation and chemotherapy have yielded only limited benefits to a minority of the population at risk.4,5,7–12 As expected, these cases have been accompanied by significant side effects and complications.13,14 Regrettably, anticipated refinements in standard therapies are not expected to appreciably improve the prognosis for patients with malignant gliomas.9,15,16


Malignant Glioma Malignant Brain Tumor Anaplastic Glioma Hyperthermia Treatment Thermal Dose 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • J. Alexander Marchosky
    • 1
  • Charles F. Babbs
    • 2
  • Christopher J. Moran
    • 3
  • Neal E. Fearnot
    • 2
  • John A. DeFord
    • 2
  • Deborah M. Welsh
    • 4
  1. 1.Neurosurgical AssociatesSt. LouisUSA
  2. 2.Hillenbrand Biomedical Engineering CenterPurdue UniversityWest LafayetteUSA
  3. 3.Missouri Baptist Medical CenterSt. LouisUSA
  4. 4.St. Luke’s HospitalChesterfieldUSA

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