Unique Calcium Binding Proteins in Invertebrates

  • Jos A. Cox
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 269)


The research on sarcoplasmic calcium-binding proteins (SCP) started in 1973 in Geneva and has its roots in the, at-that-time, intense research on parvalbumins. Parvalbumins form a rather homogeneous sub-family of the EF hand calcium-binding proteins with a distribution in nearly all vertebrates. In search of parvalbumins in invertebrate muscle we discovered another type of soluble sarcoplasmic calcium-binding protein in Crustacea, annelids, mollusks and protochordates. Recently it became evident that a marked homology exists between SCP’s and other members of the EF-hand family, namely with aequorin and luciferin-binding protein and with a Streptomyces erythraeus calcium-binding protein, the first sequenced EF-hand protein of a prokaryote. All these proteins can be classified in one EF-hand subfamily, i.e. the SARC*AEQ double family.


Complete Amino Acid Sequence Positive Cooperativity Fast Skeletal Muscle Physiological Ionic Strength Patinopecten Yessoensis 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Jos A. Cox
    • 1
  1. 1.Department of BiochemistryUniversity of GenevaGeneva 4Switzerland

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