Unique Calcium Binding Proteins in Invertebrates
The research on sarcoplasmic calcium-binding proteins (SCP) started in 1973 in Geneva and has its roots in the, at-that-time, intense research on parvalbumins. Parvalbumins form a rather homogeneous sub-family of the EF hand calcium-binding proteins with a distribution in nearly all vertebrates. In search of parvalbumins in invertebrate muscle we discovered another type of soluble sarcoplasmic calcium-binding protein in Crustacea, annelids, mollusks and protochordates. Recently it became evident that a marked homology exists between SCP’s and other members of the EF-hand family, namely with aequorin and luciferin-binding protein and with a Streptomyces erythraeus calcium-binding protein, the first sequenced EF-hand protein of a prokaryote. All these proteins can be classified in one EF-hand subfamily, i.e. the SARC*AEQ double family.
KeywordsComplete Amino Acid Sequence Positive Cooperativity Fast Skeletal Muscle Physiological Ionic Strength Patinopecten Yessoensis
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- Buchner, E., Bader, R., Buchner, S., Cox, J.A., Emson, P.C., Flory, E., Heizmann, C.W., Hemm, S., Hofbauer, A., and Oertel, W.H., 1988, Cell-specific immuno-probes for the brain of normal and mutant Drosophila melanogaster. I Wildtype visual system. Cell Tissue Res. 253: 357–370.PubMedCrossRefGoogle Scholar
- Cox, J A., Kretsinger, R.H., and Stein, E.A., 1980, Sarcoplasmic calcium-binding proteins in insect muscle. Isolation and properties of locust calmodulin. Biochim. Biophys. Acta 670: 441–444.Google Scholar
- Kretsinger, R., Moncrief, N.D., Goodman, M., and Czelusniak, J., 1988, Homology of calcium-modulated proteins: Their evolutionary and functional relationships. in: “The Calcium Channel: Structure, Function and Implications”, M. Morad, W. Nayler, S. Kazda, and M. Schramm, eds., pp. 16–38, Springer-Verlag, Berlin Heidelberg.Google Scholar
- Wnuk, W., Cox, J.A., and Stein, E.A., 1982, Parvalbumin and other soluble sarcoplasmic Ca-binding proteins, in: “Calcium and Cell Function”, W.Y. Cheung, ed., Vol II, pp. 243–278, Academic Press, New York.Google Scholar