Parvalbumin Expression in Normal and Mutant Xenopus Embryos
Our laboratory is interested in understanding the developmental regulation of the Ca2+-binding protein, parvalbumin, in embryos. We wish to learn how the various members of the parvalbumin gene family are differentially expressed, and what the individual isoforms contribute to muscle cell structure and function. Parvalbumin is a member of the troponin C superfamily and is evolutionarily related to a number of Ca2+-binding proteins, including calmodulin, troponin C., regulatory myosin light chains, oncomodulin, intestinal vitamin D-dependent calcium-binding protein, and Spec 1 protein (Goodman et al., 1979; Kretsinger, 1980; MacManus et al., 1983; Hardin et al., 1985).
KeywordsXenopus Laevis Regulatory Myosin Light Chain Myotomal Muscle Behavioral Mutant Embryonic Muscle Cell
Unable to display preview. Download preview PDF.
- Dawid, I.B., Kay, B.K. and Sargent, T.S., 1983, Gene expression during Xenopus laevis development, in: “Gene structure and regulation in development”, pp. 171–182. S. Subtelny and F.C. Kafatos, eds., Lis, Inc., New York.Google Scholar
- Nieuwkoop, P. and Faber, J., 1967, “Normal tables of Xenopus laevis (Daudin)”, 2nd ed. North-Holland Publishing Co., Amsterdam.Google Scholar
- Wnuk, W., Cox, J.A. and Stein, E.S., 1982, Paralbumins and other soluble high-affinity calcium-binding proteins from muscle. in: “Calcium and Cell Function”, vol. II. pp. 243–278. W.Y. Cheung, ed., Academic Press, New York.Google Scholar