Novel and Selective Inhibitors of CaM-Kinase II and Other Calmodulin-Dependent Enzymes

  • Hiroyoshi Hidaka
  • Masatoshi Hagiwara
  • Hiroshi Tokumitsu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 269)


Twenty years has passed since two laboratories working independently on the purification of cyclic nucleotide phosphodiesterase reported the existence of a protein factor that activated enzymatic activity (1, 2). These early observations are credited the discovery of calmodulin. Biopharmacological studies using calmodulin antagonists such as naphthalenesulfonamides and phenothiazines have facilitated an insight into calmodulin function, not only in vitro but also in vivo. Phenothiazines were the first antagonists of calmodulin to be reported (3), although they have multiple macromolecular targets inside cells such as membranes (4), albumin (5), dehydrogenases (6), and dopamine receptors (7).


Myosin Light Chain Myosin Light Chain Kinase Cyclic Nucleotide Phosphodiesterase Phosphorylates Myosin Light Chain Calmodulin Antagonist 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Hiroyoshi Hidaka
    • 1
  • Masatoshi Hagiwara
    • 1
  • Hiroshi Tokumitsu
    • 1
  1. 1.Department of PharmacologyNagoya University, School of MedicineShowa-ku, Nagoya 466Japan

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