Novel and Selective Inhibitors of CaM-Kinase II and Other Calmodulin-Dependent Enzymes
Twenty years has passed since two laboratories working independently on the purification of cyclic nucleotide phosphodiesterase reported the existence of a protein factor that activated enzymatic activity (1, 2). These early observations are credited the discovery of calmodulin. Biopharmacological studies using calmodulin antagonists such as naphthalenesulfonamides and phenothiazines have facilitated an insight into calmodulin function, not only in vitro but also in vivo. Phenothiazines were the first antagonists of calmodulin to be reported (3), although they have multiple macromolecular targets inside cells such as membranes (4), albumin (5), dehydrogenases (6), and dopamine receptors (7).
KeywordsMyosin Light Chain Myosin Light Chain Kinase Cyclic Nucleotide Phosphodiesterase Phosphorylates Myosin Light Chain Calmodulin Antagonist
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