Evolution of the “EF-Hand” Family of Calcium-Binding Proteins
The family of the intracellular calciproteins that bind calcium with an affinity constant Ka ≃ 104 to 108 M-1 includes the two vitamin D-induced calcium-binding proteins (CaBP) now termed calbindins D. In this family of proteins each calcium-binding domain is organized as a consensus structure, “EF-hand” domain (1).
KeywordsLeucine Residue Intron Insertion Consensus Structure Exon Shuffling Calpain Gene
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