Evolution of the “EF-Hand” Family of Calcium-Binding Proteins

  • Christine Perret
  • Nour-eddine Lomri
  • Monique Thomasset
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 269)


The family of the intracellular calciproteins that bind calcium with an affinity constant Ka ≃ 104 to 108 M-1 includes the two vitamin D-induced calcium-binding proteins (CaBP) now termed calbindins D. In this family of proteins each calcium-binding domain is organized as a consensus structure, “EF-hand” domain (1).


Leucine Residue Intron Insertion Consensus Structure Exon Shuffling Calpain Gene 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Christine Perret
    • 1
  • Nour-eddine Lomri
    • 1
  • Monique Thomasset
    • 1
  1. 1.U 120INSERMLe VésinetFrance

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