High Levels of Oncomodulin and Calmodulin Expression in the Log Phase of Cell Growth in a Chemically Transformed Rat Fibroblast Cell Line
A variety of cellular processes are under the regulatory control of calcium. Alterations in fluxes and steady state levels of intracellular calcium appear to be responsible for evoking these events. Calcium homeostasis has been reported to be altered during tumorigenesis as well as upon transformation of cells in vitro by chemicals or viruses1. Neither the underlying molecular mechanisms related to calcium regulation in normal and tumor cells, nor the fact that transformed cells do not respond properly to normal regulatory controls are as yet well understood. Increased intracellular calcium levels could be partially responsible for a permanent activation of DNA synthesis and/or an increased mobility (invasive behaviour) of tumor cells.
KeywordsCalmodulin Gene Morris Hepatoma Proliferate Granulation Tissue Phase Specific Expression T14c Cell
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- 7.H. Nojima and H. Sokabe, Structure of calmodulin genes in the rat genome. In: “Ca2+ signalling”, H. Hidaka, ed., Plenum Press, in press (1989)Google Scholar