Ca2+-Binding Proteins as Components of the Cytoskeleton
One of the major filamentous systems of non-muscle cells is based on actin, a highly conserved protein of 42kD. The polymerization equilibrium between globular (G-) and filamentous (F-) actin determines the viscosity of the cytoplasm and is regulated by cytoplasmic salt conditions and by actin-binding proteins (for review see Stossel et al., 1985, Pollard and Cooper, 1986). Several of these actin-binding proteins are activated or inhibited by micromolar Ca2+-concentrations either through direct binding to Ca2+ or indirectly through modulators such as calmodulin.
KeywordsDictyostelium Discoideum Chicken Brain 42bp Oligonucleotide Chicken Fibroblast Brain Spectrin
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