Role of Calcium in Secretion and Synthesis in Bovine Adrenal Chromaffin Cells
Secretion of many neurotransmitters, hormones and enzymes has long been known to require extracellular calcium (Douglas 1968; Katz 1969) and this fact was important in formulating the idea that a rise in intracellular calcium is the trigger for secretion. Additional data corroborating the role of calcium in secretion were obtained from measurements of calcium influx associated with secretion and in triggering secretion by introducing calcium directly into the cytosol. To date, the role of calcium as the triggering and controlling agent in the secretory process has been firmly established, but the question of what this role entails still awaits elucidation.
KeywordsActin Filament Secretory Granule Chromaffin Cell Catecholamine Release Secretory Process
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- Katz B., 1969, “The Release of Neurotransmitter Substances”, Liverpool University Press, LiverpoolGoogle Scholar