Growth Factor, Oncogene, and Steroidal Interactions in the Regulation of Uterine Growth and Function

  • D. S. Loose-Mitchell
  • C. Chiappetta
  • R. M. Gardner
  • J. L. Kirkland
  • T.-H. Lin
  • R. B. Lingham
  • V. R. Mukku
  • C. Orengo
  • G. M. Stancel
Part of the Reproductive Biology book series (RBIO)


Historically, most studies of uterine growth and function in the non-pregnant uterus focused on the hormones estradiol and progesterone. In some cases, other hormones such as growth hormone (Grattarola and Li, 1959), triclothymine (T3, Gardner et al., 1978: Kirkland et al., 1981 a) insulin (Kirkland et al., 1981 b; Fowler et al., 1963) and glucocorticoids (Szego and Roberts, 1953; Campbell, 1978) were also studied, but the principal emphasis remained on the two ovarian hormones noted above. These studies emphasized the structure, function, and regulation of steroid receptors; nuclear interactions of receptors; and biological responses resulting from hormonal stimulation of the tissue (Jensen and DeSombre, 1972; Gorski and Gannon, 1976). During this time, scant attention was given to possible interactions between steroids and polypeptide growth factors in the regulation of uterine growth and function.


Epidermal Growth Factor Estrogen Treatment Uterine Epithelial Cell Epidermal Growth Factor Receptor mRNA Estrogen Responsive Element 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • D. S. Loose-Mitchell
    • 1
  • C. Chiappetta
    • 1
  • R. M. Gardner
    • 1
  • J. L. Kirkland
    • 2
  • T.-H. Lin
    • 2
  • R. B. Lingham
    • 1
  • V. R. Mukku
    • 1
  • C. Orengo
    • 1
  • G. M. Stancel
    • 1
  1. 1.Department of PharmacologyThe University of Texas Medical SchoolHoustonUSA
  2. 2.Division of Endocrinology, Department of PediatricsBaylor College of MedicineHoustonUSA

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