Mullerian Inhibiting Substance: Studies on its Mechanism of Action and Activity as an Anti-Tumor Agent

  • David T. MacLaughlin
  • James Epstein
  • Patricia K. Donahoe
Part of the Reproductive Biology book series (RBIO)


The urogenital ridge of the developing mammalian embryo is a complex structure in which the Wolffian and Mullerian ducts, each comprised of luminal epithelium surrounded by mesenchyme, develop side by side. As the maturing gonad begins to declare its genetic sex as either an ovary or testis, significant changes occur in the ducts contained within the urogenital ridge. If the gonad is an ovary the Wolffian duct, which develops into the epididymis, vas deferens, and seminal vesicles of the male, begins to atrophy while the Mullerian ducts expand. Conversely, testicular development coincides with the regression of the Mullerian ducts, the precursor of the ovarian coelomic epithelium, Fallopian tubes, uterus, cervix, and upper third of the vagina. As expected in this case, the Wolffian duct continues to enlarge.


Epidermal Growth Factor Receptor Epidermal Growth Factor Wolffian Duct Mullerian Duct Mullerian Inhibit Substance 


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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • David T. MacLaughlin
    • 1
  • James Epstein
    • 2
  • Patricia K. Donahoe
    • 2
  1. 1.Vincent Research LaboratoryMassachusetts General HospitalBostonUSA
  2. 2.Pediatric Surgical Research LaboratoryMassachusetts General HospitalBostonUSA

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