Morphogenesis and Cytodifferentiation of Male Sex Accessory Epithelia: Involvement of the Mesenchyme and Neurotransmitters

  • Stephen J. Higgins
  • Gerald R. Cunha
  • Peter Young
  • Annemarie A. Donjacour
  • E. Margaret Kinghorn
Part of the Reproductive Biology book series (RBIO)


Androgenic steroid hormones characteristically regulate the expression of specific genes within their target organs (Higgins and Parker, 1980; Cunha et al., 1987). Since the advent of recombinant DNA technology, considerable progress has been made in our understanding of how androgens and other steroid hormones selectively activate gene expression (Evans, 1988; Green and Chambon, 1988). With the recent cloning of the androgen receptor (AR) gene (Lubahn et al., 1988; Chang et al., 1988 a,b; Trapman et al., 1988), further dramatic advances can be expected. Little attention, however, has been given to the possible roles of paracrine and autocrine mechanisms in androgen action. This chapter describes some of our studies concerning such mechanisms in the functional cytodifferention of male sex accessory organs and in the maintenance of the differentiated state.


Androgen Receptor Seminal Vesicle Androgen Action Wolffian Duct Epididymal Protein 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Stephen J. Higgins
    • 1
  • Gerald R. Cunha
    • 2
  • Peter Young
    • 3
  • Annemarie A. Donjacour
    • 3
  • E. Margaret Kinghorn
    • 1
  1. 1.Department of BiochemistryUniversity of LeedsLeedsUK
  2. 2.Center for Reproductive EndocrinologyUniversity of California Medical CenterSan FranciscoUSA
  3. 3.Department of AnatomyUniversity of California Medical CenterSan FranciscoUSA

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