Prostate Growth Factor: Characterization and its Role in Normal Prostate and in Benign Prostatic Hyperplasia

  • Michael T. Story
Part of the Reproductive Biology book series (RBIO)


Benign prostatic hyperplasia (BPH) is the most common benign neoplastic growth that occurs in men. It has been estimated that 75% of males over 50 years of age have symptoms of urinary-outlet obstruction arising from BPH (Walsh, 1984). Birkhoff (1983) has estimated that the chance of a 50 year old requiring a prostatectomy during his lifetime is 20–25%. Over 350,000 surgical procedures are performed each year to relieve symptoms resulting from BPH, resulting in an overall medical cost that exceeds one billion dollars annually in the United States (Peters and Walsh, 1987). These statistics emphasize the need for new approaches to the study of BPH because, despite more than 100 years of study, the etiology of BPH has not been resolved.


Androgen Receptor Fibroblast Growth Factor Benign Prostatic Hyperplasia Basic Fibroblast Growth Factor Normal Prostate 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Michael T. Story
    • 1
  1. 1.Departments of Urology and BiochemistryMedical College of WisconsinMilwaukeeUSA

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