Advertisement

Prostate Growth Factor: Characterization and its Role in Normal Prostate and in Benign Prostatic Hyperplasia

  • Michael T. Story
Part of the Reproductive Biology book series (RBIO)

Abstract

Benign prostatic hyperplasia (BPH) is the most common benign neoplastic growth that occurs in men. It has been estimated that 75% of males over 50 years of age have symptoms of urinary-outlet obstruction arising from BPH (Walsh, 1984). Birkhoff (1983) has estimated that the chance of a 50 year old requiring a prostatectomy during his lifetime is 20–25%. Over 350,000 surgical procedures are performed each year to relieve symptoms resulting from BPH, resulting in an overall medical cost that exceeds one billion dollars annually in the United States (Peters and Walsh, 1987). These statistics emphasize the need for new approaches to the study of BPH because, despite more than 100 years of study, the etiology of BPH has not been resolved.

Keywords

Androgen Receptor Fibroblast Growth Factor Benign Prostatic Hyperplasia Basic Fibroblast Growth Factor Normal Prostate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abraham J.A., Mergia A., Whang J.L., Tumola A., Friedman J., Hjerrild K.A., Gospodarowicz D. and Fiddes J.-C. 1986. Nucleotide sequence of a bovine clone encoding the angiogenic protein basic fibroblast growth factor. Science 133:545.CrossRefGoogle Scholar
  2. Baird A., Bohlen P., Ling N. and Guillemin R. 1985a. Radioimmunoassay for fibroblast growth factor (FGF): release by the bovine anterior pituitary in vitro. Regul. Peptides 10:309.CrossRefGoogle Scholar
  3. Baird A., Esch F., Bohlen P., Ling N. and Gospodarowicz D. 1985b. Isolation and partial characterization of an endothelial cell growth factor from the bovine kidney: homology with basic fibroblast growth factor. Regul. Peptides 12:201.CrossRefGoogle Scholar
  4. Baird A. and Ling N. 1987. Fibroblast growth factors are present in the extracellular matrix produced by endothelial cells in vitro: Implications for a role of heparinase-like enzymes in the neovascular response. Biochem. Biophys. Res. Commun. 142:429.CrossRefGoogle Scholar
  5. Baird A., Mormed P. and Bohlen P. 1986. Immunoreactive fibroblast growth factor (FGF) in a transplantable chondrosarcoma: Inhibition of tumor growth by antibodies to FGF. J. Cell. Biochem. 30:79.PubMedCrossRefGoogle Scholar
  6. Birkhoff J.D. 1983. Natural history of benign prostatic hypertrophy. In: “Benign Prostatic Hypertrophy”, (F. Hinman, ed.) Springer-Verlag, New York. p.5.CrossRefGoogle Scholar
  7. Bovi P.D., Curatola A.M., Kern F.G., Greco A., Ittman M. and Baslico C. 1987 An oncogene isolated by transfection of Kaposi’s sarcoma DNA encodes a growth factor that is a member of the FGF family. Cell 50:729.CrossRefGoogle Scholar
  8. Coffey D.S. 1986. The biochemistry and physiology of the prostate and seminal vesicles. In: “Campbell’s Urology, 5th ed., vol. 1” (P.C. Walsh, R.F. Gittes, A.D. Perlmutter, and T.A. Stamey, eds.) Saunders, Philadelphia, p.283.Google Scholar
  9. Cunha G.R. 1984. Androgenic effects upon prostatic epithelium via trophic influences from stroma. In: “New Approaches to the Study of Benign Prostatic Hyperplasia” (F.A. Kimball, A.F. Buhl, D.B. Carter, eds.) Alan R. Liss, Inc., New York. p.81.Google Scholar
  10. Deming C.L. and Neumann C. 1939. Early phases of prostatic hyperplasia. Surg. Gynec. Obstet. 68:155.Google Scholar
  11. Dickson C. and Peters G. 1987. Potential oncogene product related to growth factors. Nature (London) 326:833.CrossRefGoogle Scholar
  12. Doolittle R.F., Hunkapiller M.W., Hood L.E., DeVare S.G., Robbins K.C., Aaronson S.A. and Antoniades H.N. 1983. Simian sarcoma virus oncogene, v-sis, is derived from the gene (oncogenes) encoding a platelet derived growth factor. Science 221:275.PubMedCrossRefGoogle Scholar
  13. Downward J., Yarden Y., Mayes E., Scrace G., Totty N., Stockwell P., Ullrich A., Schlessinger J. and Waterfield M.D. 1984. Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences. Nature (London) 307:521.CrossRefGoogle Scholar
  14. Esch F., Baird A., Ling N., Ueno N., Hill F., Denoroy L., Kleppe R., Gospodarowicz D., Bohlen P. and Guillemin R.L. 1985. Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF. Proc. Natl. Acad. Sci. (USA) 82:6507.CrossRefGoogle Scholar
  15. Folkman J. and Klagsbrun M. 1987. Angiogenic factors. Science 235:442.PubMedCrossRefGoogle Scholar
  16. Friesel R., Burges W.H., Mehlman T. and Maciag T. 1986. The characterization of the receptor for endothelial cell growth factor by covalent ligand attachment. J. Biol. Chem. 261:7581.PubMedGoogle Scholar
  17. Gauthier T., Maftouh M. and Picard C. 1987. Rapid enzymatic degradation of (125I) (Tyr 10) FGF (1–10) by serum in vitro and involvement in the determination of circulating FGF by RIA. Biochem. Biophys. Res. Commun. 145:775.PubMedCrossRefGoogle Scholar
  18. Gospodarowicz D. 1974. Localization of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth. Nature (London) 249:123.CrossRefGoogle Scholar
  19. Gospodarowicz D. 1985. Biological activity in vivo and in vitro of pituitary and brain fibroblast growth factor. In: “Mediators in Cell Growth and Differentiation” (R.J. Ford and A.L. Maizel, eds.) Raven Press, New York. p.109.Google Scholar
  20. Gospodarowicz D., Baird A., Cheng J., Lui G.M., Esch F. and Bohlen P. 1986a. Isolation of fibroblast growth factor from bovine adrenal gland: physiochemical and biological characterization. Endocrinology 118:82.PubMedCrossRefGoogle Scholar
  21. Gospodarowicz D., Cheng J., Lui G.M., Baird A., Esch F. and Bohlen P. 1985. Corpus luteum angiogenic factor is related to fibroblast growth factor. Endocrinology 117:2383.PubMedCrossRefGoogle Scholar
  22. Gospodarowicz D., Ferrara N., Schweigerer L. and Neufeld G. 1987. Structural characterization and biological functions of fibroblast growth factor. Endocrine Rev. 8:95.CrossRefGoogle Scholar
  23. Gospodarowicz D., Neufeld G. and Schweigerer S. 1986b. Fibroblast growth factor. Mol. Cell. Endocrinol. 46:187.PubMedCrossRefGoogle Scholar
  24. Halaban R., Ghosh S. and Baird A. 1987. bFGF is the putative natural growth factor from human melanocytes. In Vitro Cell Dev. Biol. 23:47.PubMedCrossRefGoogle Scholar
  25. Hunter J., 1841, Observations on certain parts of the animal economy. In: “The Complete Works of John Hunter, vol. 4”, (J.E. Palmer, ed.) Haswell, Barrington, and Haswell, Philadelphia, p.68.Google Scholar
  26. Jacobs S.C. and Lawson R.K. 1980. Mitogenic factors in human prostate extracts. Urology 16:488.PubMedCrossRefGoogle Scholar
  27. Jacobs S.C. and Pikna D. and Lawson R.K. 1979. Prostatic osteoblastic factor. Invest. Urol. 17:195.PubMedGoogle Scholar
  28. Jaye M., Lyall R.M., Mudd R., Schlessinger J. and Sarver N. 1988. Expression of acidic fibroblast growth factor cDNA confers growth advantage and tumorigenesis to Swiss 3T3 cells. EMBO J. 7:963.PubMedGoogle Scholar
  29. Klagsbrun M., Sasse J., Sullivan R. and Smith J.A. 1986. Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor. Proc. Natl. Acad. Sci. (USA) 83:2448.CrossRefGoogle Scholar
  30. Klagsbrun M., Smith S., Sullivan K., Shing Y., Davidson S., Smith J.A. and Sasse J. 1987. Multiple forms of basic fibroblast growth factor: Amino-terminal cleavages by tumor cell-and brain cell-derived acid proteinases. Proc. Natl. Acad. Sci. (USA) 84:1839.CrossRefGoogle Scholar
  31. Krieg M., Bartsch W., Thomsen M. and Voigt K.D. 1983. Androgens and estrogens. Their interactions with stroma and epithelium of human benign prostatic hyperplasia and normal prostate. J. Steroid. Biochem. 19:155.PubMedCrossRefGoogle Scholar
  32. Kurokawa T., Sasada R., Iwan M. and Igarashi K. 1987. Cloning and expression of cDNA encoding human basic fibroblast growth factor. FEBS Lett. 213:189.PubMedCrossRefGoogle Scholar
  33. Lahtonen R., Bolton N.J., Kontturi M. and Vihko R. 1983. Nuclear androgen receptors in the epithelium and stroma of human benign prostatic hypertrophic glands. Prostate 4:129.PubMedCrossRefGoogle Scholar
  34. Lawson R.K., Story M.T., and Jacobs S.C. 1981. A growth factor in extracts of human prostatic tissue. In: “The Prostatic Cell: Structure and Function, Part A”, (G.P. Murphy, A.A. Sandberg and J.P. Karr, eds.) Alan R. Liss Inc., New York. p.325.Google Scholar
  35. Lawson R.K. 1986. The natural history of benign prostatic hyperplasia. In: “AUA Update Series, vol. 5” (T.P. Ball, Jr., ed.) American Urological Association, Inc., Houston, Texas, p.2.Google Scholar
  36. Lawson R.K. 1988. Growth factor and benign prostatic hyperplasia. World J. Urol. (in press).Google Scholar
  37. LeDuc I.E. 1939. The anatomy of the prostate and the pathology of early benign hypertrophy. J. Urol. 42:1217.Google Scholar
  38. Lee C. 1981. Physiology of castration-induced regression in rat prostate. In: “The Prostatic Cell: Structure and Function, Part A”, (G.P. Murphy, A.A. Sandberg and J.P. Karr, eds.) Alan R. Liss, Inc., New York. p.145.Google Scholar
  39. Lobb R. and Fett J. 1984. Purification of two distinct growth factors from bovine neural tissue by heparin affinity chromatography. Biochemistry 23:6295.PubMedCrossRefGoogle Scholar
  40. Massoglia S.L., Kenney J.S. and Gospodarowicz D. 1987. Characterization of murine monoclonal antibodies directed against basic fibroblast growth factor. J. Cell Physiol. 132:531.PubMedCrossRefGoogle Scholar
  41. Matzner Y., Bar-Ner M., Yahalom J., Ishai-Michaeli R., Fuks Z. and Vlodavsky I. 1985. Degradation of heparin sulfate in the subendothelial extracellular matrix by a readily released heparanase from human neutrophile. J. Clin. Invest. 76:1306.PubMedCrossRefGoogle Scholar
  42. McNeal J.E. 1984. Anatomy of the prostate and morphogenesis of BPH. In: “New Approaches to the Study of Benign Prostatic Hyperplasia, Part A”, (F.A. Kimball, A.E. Buhl and D.B. Carter, eds.) Alan R. Liss, Inc., New York. p.145.Google Scholar
  43. Moenner M., Chevallier B., Badet J. and Barritault D. 1986. Evidence and characterization of the receptor to eye-derived growth factor I, the retinal form of basic fibroblast growth factor, on bovine epithelial lens cells. Proc. Natl. Acad. Sci. (USA) 83:5024.CrossRefGoogle Scholar
  44. Moore R.A. 1943. Benign hypertrophy of the prostate: a morphological study. J. Urol. 50:680.Google Scholar
  45. Moore R.A. 1944. Benign hypertrophy and carcinoma of the prostate: occurrence and experimental production in animals. Surgery 16:152.Google Scholar
  46. Moscatelli D. 1987. High and low affinity binding sites for basic fibroblast growth factor on cultured cells; absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells. J. Cell Physiol. 131:123.PubMedCrossRefGoogle Scholar
  47. Moscatelli D., Presta M., Joseph-Silverstein J. and Rifkin D.B. 1986. Both normal and tumor cell produce basic fibroblast growth factor. J. Cell Physiol. 129:273.PubMedCrossRefGoogle Scholar
  48. Neufeld G. and Gospodarowicz D. 1985. The identification and partial characterization of the fibroblast growth factor receptor of baby hamster kidney cells. J. Biol. Chem. 260:13860.PubMedGoogle Scholar
  49. Neufeld G. and Gospodarowicz D. 1986. Basic and acidic fibroblast growth factors interact with the same cell surface receptors. J. Biol. Chem. 261:5631.PubMedGoogle Scholar
  50. Olwin B.B. and Hauschka S.D. 1986. Identification of the fibroblast growth factor receptor of Swiss 3T3 cells and mouse skeletal muscle myoblasts. Biochemistry 25:3487.PubMedCrossRefGoogle Scholar
  51. Peters C.A. and Barrack E.R. 1986. Androgen receptor localization in the prostate using a new method of steroid receptor autoradiography. In: “Benign Prostatic Hyperplasia, vol. 2”, (C.H. Rogers, ed.) U.S. Govt. Printing Office, Washington, D.C. p.175.Google Scholar
  52. Peters C.A. and Walsh P.C. 1987. The effect of nafarelin acetate, a luteinizing-hormone-releasing hormone agonist, on benign prostatic hyperplasia. New England J. Med. 317:599.CrossRefGoogle Scholar
  53. Reischauer F. 1925. Die entystehung der sogenannten prostatahypertrophie. Virchow’s Arch. Path. Anat. 256:357.CrossRefGoogle Scholar
  54. Schreiber A.B., Kenney J., Kowalski W.J., Friesel R., Mehlman T. and Maciag T. 1985. Interaction of endothelial cell growth factor with heparin: characterization by receptor and antibody recognition. Proc. Natl. Acad. Sci. (USA) 82:6138.CrossRefGoogle Scholar
  55. Schweigerer L., Neufeld G., Friedman J., Abraham J.A., Fiddes J.C. and Gospodarowicz D. 1987. Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth. Nature 325:257.PubMedCrossRefGoogle Scholar
  56. Shing Y., Folkman J., Sullivan R., Butterfield C., Murray J. and Klagsbrun M. 1984. Heparin affinity: purification of a tumor-derived capillary endothelial cell growth factor. Science 223:1296.PubMedCrossRefGoogle Scholar
  57. Story M.T., Esch F., Shimasaki S., Sasse J., Jacobs S.C. and Lawson R.K. 1987a. Amino-terminal sequence of a large form of basic fibroblast growth factor isolated from human benign prostatic hyperplastic tissue. Biochem. Biophys. Res. Commun. 142:702.PubMedCrossRefGoogle Scholar
  58. Story M.T., Jacobs S.C. and Lawson R.K. 1983. Epidermal growth factor is not the major growth-promoting agent in extracts of prostatic tissue. J. Urol. 30:175.Google Scholar
  59. Story M.T., Jacobs S.C. and Lawson R.K. 1984a. Partial purification of a prostatic growth factor. J. Urol. 132:1212.PubMedGoogle Scholar
  60. Story M.T., Jacobs S.C. and Lawson R.K. 1984b. Preliminary characterization and evaluation of techniques for the isolation of prostate-derived growth factor. In: “New Approaches to the Study of Benign Prostatic Hyperplasia”, (F.A. Kimball, A.E. Buhl, D.B. Carter, eds.) Alan R. Liss, Inc., New York. p.197.Google Scholar
  61. Story M.T., Jacobs S.C. and Lawson R.K. 1988a. Identification of basic fibroblast growth factor in cultured fibroblasts from normal and BPH prostate. J. Urol. 139:190A.Google Scholar
  62. Story M.T., Sasse J., Jacobs S.C. and Lawson R.K. 1987b. Prostatic growth factor: Purification and structural relationship to basic fibroblast growth factor. Biochemistry 26:3843.PubMedCrossRefGoogle Scholar
  63. Story M.T., Sasse J., Kakuska D., Jacobs S.C. and Lawson R.K. 1988b. A growth factor in bovine and human testes that is structurally related to basic fibroblast growth factor. J. Urol. 140:422.PubMedGoogle Scholar
  64. Ueon N., Baird A., Esch F., Ling N. and Guillemin R. 1987. Isolation and partial characterization of basic fibroblast growth factor from bovine testes. Mol. Cell. Endocrinol. 49:189.CrossRefGoogle Scholar
  65. Vlodavsky I., Folkman J., Sullivan R., Fridman R., Ishni-Michaeli R., Sasse J. and Klagsbrun M. 1987. Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix. Proc. Natl. Acad. Sci. (USA) 84:2292.CrossRefGoogle Scholar
  66. Vlodavsky I., Fuks Z., Bar-Ner M., Ariav Y. and Schirrmacher V. 1983. Lymphoma cells mediated degradation of sulfated protoglycans in the subendothelial extracellular matrix: relationship to tumor cell metastasis. Cancer Research 43:2704.PubMedGoogle Scholar
  67. Walsh P.C. 1984. Human prostatic hyperplasia: etiological considerations. In: “New Approaches to the Study of Benign Prostatic Hyperplasia”, (F.A. Kimball, A.E. Buhl and D.B. Carter, eds.) Alan R. Liss, Inc., New York. p.1.Google Scholar
  68. Yoshida T., Miyagawa K., Odagiri H., Sakamoto H., Little PFR., Terada M. and Sugimura T. 1987. Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein. Proc. Natl. Acad. Sci. (USA) 84:7305.CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Michael T. Story
    • 1
  1. 1.Departments of Urology and BiochemistryMedical College of WisconsinMilwaukeeUSA

Personalised recommendations