Oncogenic Transformation by Basic Fibroblast Growth Factor

  • Snezna Rogelj
  • Michael Klagsbrun
Part of the Reproductive Biology book series (RBIO)


Several years ago Sporn and Todaro proposed autocrine growth stimulation as a mechanism for cellular transformation (Sporn and Todaro, 1980). According to this model, continuous proliferation occurs in a cell that possesses the cognate receptor for a growth factor that the cell secretes, (Long et al., 1985; Rosenthal et al., 1986; Finzi et al., 1987; Watanabe et al., 1987). This has been shown to be the cause of oncogenic conversion by numerous growth factors, including sis, epidermal growth factor (EGF), CSF-1, GM-CSF, and transforming growth factor α (TGF α) (Doolittle et al., 1983; Rosenthal et al., 1986; Stern et al., 1987; Waterfield et al., 1983; Wheeler et al., 1986).


Signal Peptide Long Terminal Repeat Basic Fibroblast Growth Factor Bovine Aortic Endothelial Cell Type Alpha 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Snezna Rogelj
    • 1
  • Michael Klagsbrun
    • 1
  1. 1.Children’s HospitalHarvard Medical SchoolBostonUSA

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