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Autocrine and Paracrine Mechanisms in Reproductive Endocrinology pp 137–155Cite as

A Role for the Extracellular Matrix in Autocrine and Paracrine Regulation of Tissue-Specific Functions

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Part of the book series: Reproductive Biology ((RBIO))

Abstract

How can the knowledge gained in characterizing a functional epithelial cell model in culture shed light on the autocrine and paracrine mechanisms of gene regulation? Our purpose in presenting the following brief description of mammary epithelial cell culture is two-fold. First, to suggest that functional cells should be prerequisite for studying the effects and relationships between the cell and the multitude of growth factors and hormones that interact with tissues. Second, to emphasize the role of the extracellular matrix (ECM) in obtaining the “correct” functional phenotype for epithelial cells in culture. These aims are by no means all inclusive. There are many new and interesting reports of the effects of growth factors in mammary gland that we will not discuss in detail here, including exciting research that addresses how ECM and soluble factors interact in vivo. For example, the recent results indicating that transforming growth factor-β (TGF-β) acts as a negative regulator of ductal growth in virgin gland (Silbertstein and Daniel, 1987) may involve the ECM, since TGF-β appears to be intimately involved in synthesis and degradation of ECM molecules (Sporn et al., 1987).

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  1. Division of Cell and Molecular Biology, Lawrence Berkeley Laboratory, Berkeley, CA, 94720, USA

    M. H. Barcellos-Hoff & M. J. Bissell

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  1. M. H. Barcellos-Hoff
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  1. Rockefeller University, New York, New York, USA

    Lewis C. Krey

  2. National Institutes of Health, Bethesda, Maryland, USA

    Bela J. Gulyas

  3. Worcester Foundation for Experimental Biology, Shrewsbury, Massachusetts, USA

    John A. McCracken

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Barcellos-Hoff, M.H., Bissell, M.J. (1989). A Role for the Extracellular Matrix in Autocrine and Paracrine Regulation of Tissue-Specific Functions. In: Krey, L.C., Gulyas, B.J., McCracken, J.A. (eds) Autocrine and Paracrine Mechanisms in Reproductive Endocrinology. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5751-3_10

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