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Growth Hormones: Expression, Structure and Protein Engineering

  • K. G. Skryabin
  • P. M. Rubtsov
  • V. G. Gorbulev
  • A. A. Schulga
  • A. Sh. Parsadanian
  • M. P. Kirpichnikov
  • A. A. Bayev
  • A. G. Pavlovskii
  • S. N. Borisova
  • B. K. Vainstein
  • A. A. Bulatov
Part of the NATO ASI Series book series (NSSA, volume 183)

Abstract

The growth hormones (GHs) are polypeptide hormones with molecular weight of 22 kD consisting of one chain. GHs are synthesized in an anterior lobe of hypophysis as a precursors with molecular weight of 25 kD. These hormones are necessary for the normal growth and development of organism and play an essential role in regulation of anabolic processes. The characteristic features of GHs are species specificity and multiple biological activity. Cloning and sequencing of DNA complementary to the rat GH messenger RNA in 1977 represented one of the first mammalian cDNA to be analyzed (Seeburg et al, 1977). Since then a variety of cDNAs corresponding to members of GH family from different vertebrates have been isolated and analyzed. These cDNAs have been used to produce the hormones in bacteria and eucaryotic cells by recombinant DNA techniques.

Keywords

Growth Hormone Human Growth Hormone Growth Hormone Gene Nontranslated Region Growth Hormone cDNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • K. G. Skryabin
    • 1
  • P. M. Rubtsov
    • 1
  • V. G. Gorbulev
    • 1
  • A. A. Schulga
    • 1
  • A. Sh. Parsadanian
    • 1
  • M. P. Kirpichnikov
    • 1
  • A. A. Bayev
    • 1
  • A. G. Pavlovskii
    • 2
  • S. N. Borisova
    • 2
  • B. K. Vainstein
    • 2
  • A. A. Bulatov
    • 3
  1. 1.Engelhardt Institute of Molecular BiologyAcademy of Sciences of the USSRRussia
  2. 2.Institute of CrystallographyAcademy of Medical Sciences of the USSRMoscowRussia
  3. 3.Institute of Experimental Endocrinology and Hormone ChemistryAcademy of Medical Sciences of the USSRMoscowRussia

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