Spectroscopy of Molecular Structure and Dynamics
Dynamic aspects of molecular structure at atomic resolution have become of increasing importance as experimental and theoretical methods have been improving for the analysis of molecular motions (Frauenfelder et al., 1979; Artemiuk et al, 1979; Karplus and McCammon, 1983). Simulating the motion of individual atoms from the knowledge of their position and interatomic forces (McCammon and Harvey, 1987; Brooks et al., 1988) has opened the way to predict molecular behavior and functional aspects of molecular assemblies such as complex enzymes and nucleic acids. An important part of this approach are techniques which can provide experimental data on structural variation and motions in a time range which is accessible to molecular dynamics simulation (10-12–10-9s).
KeywordsMolecular Dynamic Simulation Fluorescence Anisotropy Fluorescence Correlation Spectroscopy Bovine Pancreatic Trypsin Inhibitor Resonant Energy Transfer
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