The Dynamics of Oligonucleotides and Peptides Determined by Proton NMR
It is widely accepted that knowledge of the structure of a biological macromolecule is an important key to understanding its biological function. On the other hand, it is known that these macromolecules have adaptable structures that are specifically modified during their interactions with their partners. This adaptability is generally due to the flexibility of structural motifs in the macromolecule that are arranged in a specific way in space. The flexibility is possible because the potential energy around the average structure of the motif is quite flat, so that the structural motif is continuously moving between several isoenergetical structures, giving rise to the so called internal motion of the macromolecule. The knowledge of this internal motion is an important step toward understanding the biological function of a macromolecule and, consequently, toward engineering macromolecules.
KeywordsCorrelation Time Relaxation Parameter Internal Motion Spectral Density Function Spin Diffusion
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