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The Dynamics of Oligonucleotides and Peptides Determined by Proton NMR

  • Patrice Koehl
  • Bruno Kieffer
  • Jean-François Lefèvre
Part of the NATO ASI Series book series (NSSA, volume 183)

Abstract

It is widely accepted that knowledge of the structure of a biological macromolecule is an important key to understanding its biological function. On the other hand, it is known that these macromolecules have adaptable structures that are specifically modified during their interactions with their partners. This adaptability is generally due to the flexibility of structural motifs in the macromolecule that are arranged in a specific way in space. The flexibility is possible because the potential energy around the average structure of the motif is quite flat, so that the structural motif is continuously moving between several isoenergetical structures, giving rise to the so called internal motion of the macromolecule. The knowledge of this internal motion is an important step toward understanding the biological function of a macromolecule and, consequently, toward engineering macromolecules.

Keywords

Correlation Time Relaxation Parameter Internal Motion Spectral Density Function Spin Diffusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Patrice Koehl
    • 1
  • Bruno Kieffer
    • 1
  • Jean-François Lefèvre
    • 1
  1. 1.Groupe de Cancerogénèse et de Mutagénèse Moléculaire et StructuraleInstitut de Biologie Moleculaire et CellulaireStrasbourgFrance

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