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G Proteins

A Family of Signal-Transducing Molecules
  • Eva J. Neer
Part of the New Horizons in Therapeutics book series (NHTH)

Abstract

The signals from many receptors for hormones and neurotransmitters are sent through the plasma membrane by a set of heterotrimeric GTP-binding proteins composed of a GTP-binding α subunit and a βγ subunit that is a nondissociable dimer made up of two different polypeptides (for recent reviews, see Gilman, 1987; Stryer and Bourne, 1986; Lochrie and Simon, 1988; Neer and Clapham, 1988). The receptors on the cell surface are extremely specific for their ligands, which have very low affinities for heterologous receptors. Thus, there is very little cross-talk due to agonist binding at an inappropriate receptor. However, the next steps in the cascade appear to be less precise. Within a single cell, several separate receptors can often regulate each final pathway. For example, in the heart, acetylcholine and adenosine receptors appear to regulate the same K+ channel (Kurachi et al., 1986).

Keywords

Adenylate Cyclase Adenylyl Cyclase Human Fetal Tissue Guanine Nucleoside Neonatal Cardiocytes 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Eva J. Neer
    • 1
  1. 1.Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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