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Genetic Analysis of Polypeptide Chain Folding and Misfolding in Vivo

  • Jonathan King
  • Ben Fane
  • Cameron Haase-Pettingell
  • Anna Mitraki
  • Robert Villafane
Part of the New Horizons in Therapeutics book series (NHTH)

Abstract

Some 30 years have passed since the first protein structures were determined by X-ray crystallography, and since Anfinsen and co-workers established that the information for determining conformation could be contained solely within the polypeptide chain (see Anfinsen, 1973). The three-dimensional structure of more than 200 proteins is known to atomic resolution. For each of these proteins, and for thousands more, the amino acid sequence is also known exactly. Yet we are only beginning to be able to predict and understand how the sequence of the amino acids along polypeptide chains determines their three-dimensional conformation.

Keywords

Polypeptide Chain Folding Pathway Folding Intermediate Subunit Assembly Chain Association 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Jonathan King
    • 1
  • Ben Fane
    • 1
  • Cameron Haase-Pettingell
    • 1
  • Anna Mitraki
    • 1
  • Robert Villafane
    • 1
  1. 1.Department of BiologyMassachusetts Institute of TechnologyCambridgeUSA

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