Knowledge-Based Protein Modeling and the Design of Novel Molecules

  • Tom L. Blundell
  • Mark S. Johnson
  • John P. Overington
  • Andrej Šali
Part of the New Horizons in Therapeutics book series (NHTH)


Each year protein crystallographers determine about 30 new three-dimensional protein structures, most of which are published in some form, and many of which are deposited in the Brookhaven Protein Databank (Bernstein et al., 1977). Some of these are novel arrangements of a polypeptide chain, but others represent classes of structure that have been observed earlier in other proteins. Thus, each year we learn about an increasing proportion of the folds available to a polypeptide chain.


Aspartic Proteinase Renin Inhibitor Distance Geometry Equivalent Residue Human Renin 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Tom L. Blundell
    • 1
  • Mark S. Johnson
    • 1
  • John P. Overington
    • 1
  • Andrej Šali
    • 2
  1. 1.Laboratory of Molecular Biology, Department of Crystallography, Birkbeck CollegeLondon UniversityLondonEngland
  2. 2.J. Stefan InstituteLjubljanaUSA

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