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Transduction in Biological Systems pp 123–141Cite as

Glucose Dose Response of Pancreatic β-Cells: Experimental and Theoretical Results

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Abstract

Islets of Langerhans are functional units of thousands of endocrine cells located within the pancreas. Approximately 85% of the cells within the islet are β-cells. β-cells secrete insulin, the hormone critical in the regulation of fuel metabolism. The major focus of insulin action is the maintenance of glucose homeostasis; however, insulin also regulates storage and breakdown of fats. Through complex interactions between the β-cells and target tissues of insulin action (liver, muscle, and fat cells), fuel homeostasis is closely regulated in both fasting and fed states.

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Author information

Authors and Affiliations

  1. Mathematics Research Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Arthur Sherman

  2. Laboratory of Cell Biology and Genetics, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA

    Patricia Carroll, Rosa M. Santos & Illani Atwater

Authors
  1. Arthur Sherman
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  2. Patricia Carroll
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  3. Rosa M. Santos
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  4. Illani Atwater
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Editor information

Editors and Affiliations

  1. Centro de Estudios Científicos de Santiago, Universidad de Chile, Santiago, Chile

    Cecilia Hidalgo  & Enrique Jaimovich  & 

  2. Universidad de Chile, Santiago, Chile

    Juan Bacigalupo

  3. University of California at Los Angeles, Los Angeles, California, USA

    Julio Vergara

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© 1990 Plenum Press, New York

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Sherman, A., Carroll, P., Santos, R.M., Atwater, I. (1990). Glucose Dose Response of Pancreatic β-Cells: Experimental and Theoretical Results. In: Hidalgo, C., Bacigalupo, J., Jaimovich, E., Vergara, J. (eds) Transduction in Biological Systems. Series of the Centro de Estudios Científicos de Santiago. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5736-0_9

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  • DOI: https://doi.org/10.1007/978-1-4684-5736-0_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5738-4

  • Online ISBN: 978-1-4684-5736-0

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