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Pharmacology of the Ryania Alkaloids: The Ester A, a Ryanodine Analog That Only Increases Sarcoplasmic Reticulum Calcium Permeability

  • John L. Sutko
  • Esther Robinson
  • Frank A. LattanzioJr.
  • Robert G. Schlatterer
  • Pierre Deslongchamps
  • Luc Ruest
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)

Abstract

Ryanodine, an alkaloid extracted from the wood of Ryania speciosa, is a specific ligand of the “foot” protein of the triad junction(1) and a modulator of sarcoplasmic reticulum (SR) calcium permeability in both striated and smooth muscles.(2–5) Ryanodine modulates the calcium permeability of sarcoplasmic reticulum terminal cisternae membranes in a complex manner. Depending on its concentration and the experimental conditions employed, ryanodine can either increase or decrease this variable.(2–4) It is important to note that either effect will reduce activation-dependent release of SR calcium in intact muscle cells.(6)

Keywords

Sarcoplasmic Reticulum Inhibitory Site Calcium Permeability Sarcoplasmic Reticulum Calcium Calcium Efflux 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • John L. Sutko
    • 1
  • Esther Robinson
    • 1
  • Frank A. LattanzioJr.
    • 1
  • Robert G. Schlatterer
    • 1
  • Pierre Deslongchamps
    • 2
  • Luc Ruest
    • 2
  1. 1.Department of PharmacologyUniversity of Nevada School of MedicineRenoCanada
  2. 2.Laboratory of Organic Synthesis, Department of Chemistry, Faculty of ScienceUniversity of SherbrookeSherbrookeCanada

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