Pharmacology of the Ryania Alkaloids: The Ester A, a Ryanodine Analog That Only Increases Sarcoplasmic Reticulum Calcium Permeability

  • John L. Sutko
  • Esther Robinson
  • Frank A. LattanzioJr.
  • Robert G. Schlatterer
  • Pierre Deslongchamps
  • Luc Ruest
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)


Ryanodine, an alkaloid extracted from the wood of Ryania speciosa, is a specific ligand of the “foot” protein of the triad junction(1) and a modulator of sarcoplasmic reticulum (SR) calcium permeability in both striated and smooth muscles.(2–5) Ryanodine modulates the calcium permeability of sarcoplasmic reticulum terminal cisternae membranes in a complex manner. Depending on its concentration and the experimental conditions employed, ryanodine can either increase or decrease this variable.(2–4) It is important to note that either effect will reduce activation-dependent release of SR calcium in intact muscle cells.(6)


Sarcoplasmic Reticulum Inhibitory Site Calcium Permeability Sarcoplasmic Reticulum Calcium Calcium Efflux 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • John L. Sutko
    • 1
  • Esther Robinson
    • 1
  • Frank A. LattanzioJr.
    • 1
  • Robert G. Schlatterer
    • 1
  • Pierre Deslongchamps
    • 2
  • Luc Ruest
    • 2
  1. 1.Department of PharmacologyUniversity of Nevada School of MedicineRenoCanada
  2. 2.Laboratory of Organic Synthesis, Department of Chemistry, Faculty of ScienceUniversity of SherbrookeSherbrookeCanada

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