Calcium Release in Skinned Muscle Fibers: Effect of Inositol 1,4,5-Trisphosphate
A key issue when postulating a role for inositol 1,4,5-trisphosphate (IP3) as a messenger in excitation-contraction coupling in skeletal muscle is whether the effect of exogenous IP3 on skeletal muscle fibers is compatible with the effect postulated for a physiological intracellular transmitter. It is important to establish then whether IP3 acts at concentrations that are low enough, whether its action is fast enough, and whether it is specific and compatible with the known physiological properties of the process.
KeywordsSarcoplasmic Reticulum Fiber Bundle Calcium Release Inositol Phosphate Skeletal Muscle Fiber
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