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Calcium Release in Skinned Muscle Fibers: Effect of Inositol 1,4,5-Trisphosphate

  • Enrique Jaimovich
  • Cecilia Rojas
  • Eduardo Rojas
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)

Abstract

A key issue when postulating a role for inositol 1,4,5-trisphosphate (IP3) as a messenger in excitation-contraction coupling in skeletal muscle is whether the effect of exogenous IP3 on skeletal muscle fibers is compatible with the effect postulated for a physiological intracellular transmitter. It is important to establish then whether IP3 acts at concentrations that are low enough, whether its action is fast enough, and whether it is specific and compatible with the known physiological properties of the process.

Keywords

Sarcoplasmic Reticulum Fiber Bundle Calcium Release Inositol Phosphate Skeletal Muscle Fiber 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Enrique Jaimovich
    • 1
  • Cecilia Rojas
    • 1
  • Eduardo Rojas
    • 2
  1. 1.Departamento de Fisiología y Biofísica, Facultad de MedicinaUniversidad de ChileSantiagoChile
  2. 2.Laboratory of Cell Biology and Genetics, National Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaUSA

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