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Monoclonal Antibodies as Probes of Triad Structure and Excitation-Contraction Coupling in Skeletal Muscle

  • Mario S. Rosemblatt
  • Gonzalo Pérez
  • Bojena Antoniu
  • Evelyn Reilley
  • Noriaki Ikemoto
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)

Abstract

It is generally accepted that the transverse tubules (T-tubules), a membrane system produced by invaginations of the plasma membrane in skeletal muscle, play a central role in the process of coupling the depolarization of the plasma membrane and muscle contraction (excitation-contraction coupling). However, the detailed molecular mechanism by which the T-tubules communicate with the intracellular membrane system of the sarcoplasmic reticulum (SR) where calcium is stored is largely unknown. Ultrastructural studies of skeletal muscle show that the T-tubules are connected to the SR at both sides through specific structures (the “feet”), forming a structural and functional unit known as a triad(1)

Keywords

Sarcoplasmic Reticulum None None French Press Frog Skeletal Muscle Transverse Tubule 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Mario S. Rosemblatt
    • 1
    • 2
  • Gonzalo Pérez
    • 1
  • Bojena Antoniu
    • 2
  • Evelyn Reilley
    • 2
  • Noriaki Ikemoto
    • 2
    • 3
  1. 1.Unidad de Immunología Celular, Instituto de Nutrición y Tecnología de los AlimentosUniversidad de ChileSantiagoChile
  2. 2.Department of Muscle ResearchBoston Biomedical Research InstituteBostonUSA
  3. 3.Department of NeurologyHarvard Medical SchoolBostonUSA

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