Molecular Architecture of T-SR Junctions: Evidence for a Junctional Complex That Directly Connects the Two Membrane Systems

  • Clara Franzini-Armstrong
  • Barbara Block
  • Donald G. Ferguson
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)


Contraction of all types of muscle fibers is activated by an increase in the cytoplasmic concentration of calcium ions. In the skeletal muscle fibers of vertebrates the calcium required for activation is released rapidly from an internal membrane system, the sarcoplasmic reticulum (SR). In other muscles release from the SR and influx through the surface membrane may contribute in variable proportion to the increase of intracellular calcium needed for myofibrillar activation. Most striated muscle fibers have extensive tubular invaginations of the surface membrane, forming networks called the transverse (T) tubular systems. Individual components are called transverse (T) tubules, even though their orientation is not always transverse to the long axis of the fiber.


Black Reaction Striate Muscle Fiber Dihydropyridine Receptor Calcium Release Channel Skeletal Muscle Sarcoplasmic Reticulum 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Clara Franzini-Armstrong
    • 1
  • Barbara Block
    • 2
  • Donald G. Ferguson
    • 3
  1. 1.Department of AnatomyUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Departments of Biology and AnatomyUniversity of PennsylvaniaPhiladelphiaUSA
  3. 3.Department of Physiology and BiophysicsUniversity of CincinnatiCincinnatiUSA

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