The Target of Inositol 1,4,5-Trisphosphate in Nonmuscle Cells: Calciosome or Endoplasmic Reticulum?

  • Pompeo Volpe
  • Mariangela Bravin
  • Barbara H. Alderson
  • Daniel P. Lew
  • Jacopo Meldolesi
  • Tullio Pozzan
Part of the Series of the Centro de Estudios Científicos de Santiago book series (SCEC)


The total calcium (Ca2+) content of mammalian cells is of the order of 1 to 3 mmoles/ liter of cell water, that is, it is similar to that of the extracellular milieu. On the other hand, the extracellular free Ca2+ concentration is about 1 mM and four orders of magnitude higher than that of the cytoplasm, which is around 100 nM. Although little information is available on the distribution of total cytoplasmic Ca2+, it is reasonable to assume that total cytoplasmic Ca2+ represents no more than 10 to 20% of cellular Ca2+ content.(1) Thus, the vast majority of the cell Ca2+ must be sequestered within intracellular, membrane-bound compartments (Ca2+ pools).


Sarcoplasmic Reticulum Rough Endoplasmic Reticulum Smooth Endoplasmic Reticulum Inositol Trisphosphate Endoplasmic Reticulum Cisterna 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Pompeo Volpe
    • 1
  • Mariangela Bravin
    • 2
  • Barbara H. Alderson
    • 1
  • Daniel P. Lew
    • 3
  • Jacopo Meldolesi
    • 4
  • Tullio Pozzan
    • 2
  1. 1.Department of Physiology and BiophysicsThe University of Texas Medical BranchGalvestonUSA
  2. 2.Centro di Studio per la Fisiologia dei Mitocondri del CNRIstituto di Patologia Generale dell’Università di PadovaPaduaItaly
  3. 3.Division des Maladies InfectieusesHôpital Cantonal UniversitaireGeneva 4Switzerland
  4. 4.Dipartimento di Farmacologia dell’ Università di Milano, Centro di Studio, di Cito Farmacologia del CNRIstituto Scientifico San RaffaeleMilanItaly

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