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Rationale for Antioxidant Therapy in Pancreatitis and Cystic Fibrosis

  • S. Uden
  • D. Bilton
  • P. M. Guyan
  • P. M. Kay
  • J. M. Braganza
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Summary

The overlapping features of the acquired diseases acute pancreatitis and chronic pancreatitis on the one hand, and of chronic pancreatitis and pancreatic involvement in the congenital condition cystic fibrosis on the other, suggest that the basic mechanism of pancreatic injury may be the same in each illness. We propose that pancreatic oxidant stress is the common denominator and, furthermore, that this is facilitated by a shortfall of micronutrient antioxidants in the face of heightened free radical activity through different sources. If so antioxidant supplements should alleviate symptoms. This deduction was supported by an exploratory dose-seeking study that spanned five years in 20 patients with recurrent (non-gall stone) acute or chronic pancreatitis and confirmed by a 20-week double-blind placebocontrolled crossover trial of the successful combination (daily doses of 600 μg organic selenium, 0.54 g vitamin C., 9000 IU B-carotene, 270 IU vitamin E and 2 g methionine) in a further 20 cases. A randomised trial of glutathione precursors, given intravenously for 24 hours after admission in patients with a first attack of acute pancreatitis, is in progress. Long term trials of oral antioxidant formulas are planned in patients with cystic fibrosis.

Keywords

Cystic Fibrosis Acute Pancreatitis Chronic Pancreatitis Acute Pancreatitis Cystic Fibrosis Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • S. Uden
    • 1
  • D. Bilton
    • 1
  • P. M. Guyan
    • 1
  • P. M. Kay
    • 1
  • J. M. Braganza
    • 1
  1. 1.The Department of GastroenterologyManchester Royal InfirmaryManchesterUK

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