Production of Superoxide Anion by Glycated Proteins: Involvement in Complications of Diabetes Mellitus
Oxygen free radicals have been implicated in the etiology of a number of disorders such as mutagenesis, radiation disease, aging, inflammation myocardial infarction, atherosclerosis, cataract or immunological disorders1. As regards diabetes mellitus, oxygen free radicals are considered likely to participate in the very early stages of the disease but they have not previously been thought to be involved in the long term diabetes complications. The results presented in this paper suggest that oxygen free radicals can be formed in increasing amounts in diabetes mellitus by an electron exchange occuring between the sugar moiety of glycated proteins and molecular oxygen.
KeywordsDiabetic Patient Oxygen Free Radical Sugar Moiety Electron Exchange Phenylboronic Acid
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- 4.J. Garst, P. Stapleton and J. Johnston. Mutagenicity of alpha hydroxyketones may involve Superoxide anion radical. In “Oxy radicals and their scavenger systems” Vol. II. R.A. Greenwald and G. Cohen, eds. Elsevier Biomedical New-York (1983) 125.Google Scholar
- 5.P. Gillery, J.C. Monboisse, F.X. Maquart and J.P. Borel. Glycation of proteins as a source of Superoxide. Diab. Metab. 14 : 25 (1988).Google Scholar
- 6.R. Selvam and C.V. Anuradha. Lipid peroxidation and antiperoxidative enzyme changes in erythrocytes in diabetes mellitus. Ind. J. Biochem. Biophys. 25 : 268 (1988).Google Scholar
- 12.A. Ceriello, D. Giugliano, A. Quatraro, P. Dello Russo and R. Torella. A preliminary note of inhibiting effect of 40 (1988).Google Scholar