Production of Superoxide Anion by Glycated Proteins: Involvement in Complications of Diabetes Mellitus

  • J. C. Monboisse
  • P. Gillery
  • F. X. Maquart
  • J. P. Borel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


Oxygen free radicals have been implicated in the etiology of a number of disorders such as mutagenesis, radiation disease, aging, inflammation myocardial infarction, atherosclerosis, cataract or immunological disorders1. As regards diabetes mellitus, oxygen free radicals are considered likely to participate in the very early stages of the disease but they have not previously been thought to be involved in the long term diabetes complications. The results presented in this paper suggest that oxygen free radicals can be formed in increasing amounts in diabetes mellitus by an electron exchange occuring between the sugar moiety of glycated proteins and molecular oxygen.


Diabetic Patient Oxygen Free Radical Sugar Moiety Electron Exchange Phenylboronic Acid 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • J. C. Monboisse
    • 1
  • P. Gillery
    • 1
  • F. X. Maquart
    • 1
  • J. P. Borel
    • 1
  1. 1.Laboratoire de Biochimie, Centre Hospitalier UniversitaireHôpital R. DebréReims CedexFrance

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