Reactivity of Active Centre Analogues of Cu2Zn2Superoxide Dismutase

  • Ulrich Weser
  • Ralf Miesel
  • Margot Linss
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


Active centre analogues of Cu2Zn2superoxide dismutase were devised and successfully employed. Emphasis was placed on the flexible nature of the Superoxide mimicking compounds. Di-Schiff-bases proved most appropri ate to fulfil these requirements. Both structural and functional aspects of the copper binding centre of the intact enzyme were met by these complexes. Nanomolar concentrations of copper coordinated in these complexes were sufficient to inhibit the K3CrO8 induced chemiluminescence identical to the reaction of Cu2Zn2superoxide dismutase.


Superoxide Dismutase Hyaluronic Acid Superoxide Dismutase Activity Copper Chelate Nitro Tetrazolium 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Ulrich Weser
    • 1
  • Ralf Miesel
    • 1
  • Margot Linss
    • 1
  1. 1.Anorganische Biochemie, Physiologisch-Chemisches InstitutUniversität TübingenTübingenGermany

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