Singlet Oxygen-Induced Damage to Rat Lenses in Vitro: Protection by Anisyldithiolthione
Oxidation is now recognized as being the major process involved m lens changes associated with cataract development (1). Visible light and near UV (300–400 nm) could be an important source of oxygen reactive species, in particular singlet oxygen Photosensitizers such as rihoíìavin and N-formylkynurenine have been shown to be present in the lens (2) Singlet oxygen provokes in vitro the same alterations in lens cristallins as those observed in aging and cataracts (3, 4) This reactive species also produces an impairment of transport systems in the rat lens (5). Furthermore, it is a powerful inducer of lipid peroxidation considered as an initiating event in cataract formation (6).
KeywordsSinglet Oxygen Rose Bengal Cataract Formation Senile Cataract Cataract Development
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- 5.M.H. Jernigan Jr. and A.S. Vallari, Effects of photo-oxidation on transport systems in lens, Lens Research. 2:159 (1985).Google Scholar