Singlet Oxygen-Induced Damage to Rat Lenses in Vitro: Protection by Anisyldithiolthione

  • Gérard Tissie
  • Elisabeth Latour
  • Claude Coquelet
  • Claude Bonne
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


Oxidation is now recognized as being the major process involved m lens changes associated with cataract development (1). Visible light and near UV (300–400 nm) could be an important source of oxygen reactive species, in particular singlet oxygen Photosensitizers such as rihoíìavin and N-formylkynurenine have been shown to be present in the lens (2) Singlet oxygen provokes in vitro the same alterations in lens cristallins as those observed in aging and cataracts (3, 4) This reactive species also produces an impairment of transport systems in the rat lens (5). Furthermore, it is a powerful inducer of lipid peroxidation considered as an initiating event in cataract formation (6).


Singlet Oxygen Rose Bengal Cataract Formation Senile Cataract Cataract Development 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Gérard Tissie
    • 1
  • Elisabeth Latour
    • 1
  • Claude Coquelet
    • 1
  • Claude Bonne
    • 2
  1. 1.Centre de Recherches Laboratoire ChauvinMontpellier cedexFrance
  2. 2.Laboratoire de Physiologie CellulaireUniversité Montpellier 1Montpellier cedexFrance

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