Free Radicals and Trials of Antioxidant Therapy in Muscle Diseases

  • M. J. Jackson
  • R. H. T. Edwards
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


It has been recognised for a number of years that the severest forms of the degenerative muscular dystrophies share many of the characteristics of vitamin E or selenium deficiency myopathy of animals and indeed the animal disorders have been incorrectly termed ’nutritional muscular dystrophies’ [Bradley and Fell, 1980]. The recognition that the major functions of vitamin E and selenium within the body are likely to be as antioxidants acting to inhibit the toxic effects of free radicals has prompted investigations of the possible role of free radicals in some of the human disorders, particularly myotonic and Duchenne muscular dystrophies.


Muscular Dystrophy Duchenne Dystrophy Duchenne Muscular Dystrophy Myotonic Dystrophy Muscle Disease 
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  1. Berneske G.M., Burton A.R.C., Gould E.N. and Levy D. (1960) Neurology 35: 61–65.Google Scholar
  2. Bertorini T.E., Palmieri G.M.A., Griffin J., Chasney C., Pifer D. et al. (1985) Neurology 35: 61–65.PubMedGoogle Scholar
  3. Bicknell F. (1940) Lancet i: 10–13.Google Scholar
  4. Bradley R. and Fell B.F. (1980). In: Disorders of Voluntary Muscle Ed. J.N. Walton. Pub. Churchill, London pp 824–872.Google Scholar
  5. Bradley W.G., Enomoto A and Gardner-Medwin D. (1977). Proc. Roy. Soc. Med. 70: 94.PubMedGoogle Scholar
  6. Burr I.M., Asayama K. and Fenichel G.M. (1987) Muscle and Nerve, 10: 150–154.PubMedCrossRefGoogle Scholar
  7. Burri B.J., Chan S.G., Gerry A.J. and Yarnell S.K. (1980) Clin. Chim. Acta. 105: 249–255.PubMedCrossRefGoogle Scholar
  8. Edwards R.H.T., Jones D.A. and Jackson M.J. (1984) Med. Biol. 62: 143–147.PubMedGoogle Scholar
  9. Fitzgerald G. and McArdle B. (1941) Brain 64: 19–42.CrossRefGoogle Scholar
  10. Gamstorp I., Gustavson K.H., Hellstron O. and Nordgren B. (1986) Child Neurol 1: 211–214.CrossRefGoogle Scholar
  11. Gebre-Medhin M., Gustavson K.H., Gamstorp I., and Plantin L.O. (1985) Acta. Paed. Scand. 7: 886–890.CrossRefGoogle Scholar
  12. Griffiths R.D., Cady E.B., Edwards R.H.T. and Wilkie D.R. (1985) Muscle and Nerve 8:760–767.PubMedCrossRefGoogle Scholar
  13. Halliwell B. and Gutteridge J.M.C. (1985) ’Free Radicals in Biology and Medicine’, Oxford Science.Google Scholar
  14. Hoffmann EP, Brown RH and Kunkel LM (1987) Cell 51: 919–928.CrossRefGoogle Scholar
  15. Hunter M.I.S., Brzeski M.S. and de Vane P.J. (1981) Clin. Chim. Acta. 115: 93–98.PubMedCrossRefGoogle Scholar
  16. Hunter M.I.S. and Mohamed J.B. (1986) Clin. Chim. Acta. 155: 123–132.PubMedCrossRefGoogle Scholar
  17. Jackson M.J. and Edwards R.H,T. (1986) Cardiomyology 5: 31–38.Google Scholar
  18. Jackson M.J., Jones D.A. and Edwards R.H.T. (1984a) Europ. J. Clin. Invest. 14: 369–374.PubMedCrossRefGoogle Scholar
  19. Jackson M.J., Jones D.A. and Edwards R.H.T. (1984b) Med. Biol. 62:135–138.PubMedGoogle Scholar
  20. Jackson M.J., Jones D.A., Edwards R.H.T., Swainbank I.G. and Coleman M.L. (1984c) Br. J. Nutr. 51: 199–208.PubMedCrossRefGoogle Scholar
  21. Jackson M.J., Jones D.A, and Edwards R.H.T. (1985) Clin. Chim. Acta. 147: 215–221.PubMedCrossRefGoogle Scholar
  22. Jackson M.J., Wagenmakers A.J.M. and Edwards R.H.T. (1987) Biochem. J. 241: 403–407.PubMedGoogle Scholar
  23. Jackson M.J., Roberts J. and Edwards R.H.T. (1988) Br. J. Nutr. 60: 217–224.PubMedCrossRefGoogle Scholar
  24. Jackson M.J., Coakley J., Stokes M., Edwards R.H.T. and Oster O. (1989) Neurology (In press).Google Scholar
  25. Kar N.C. and Pearson C.M. (1979) Clin. Chim. Acta. 94: 277–280.PubMedCrossRefGoogle Scholar
  26. Mechler F., Imre S. and Dieszeghy P. (1984) J. Neurol. Sci. 63: 279–283.PubMedCrossRefGoogle Scholar
  27. Mendel1 J.R. and Wichers D.O. (1979) Muscle and Nerve 2: 53–56.CrossRefGoogle Scholar
  28. Monaco AP, Neve RL, Colletti-Faener et al (1986) Nature 323: 646–650.PubMedCrossRefGoogle Scholar
  29. Orndahl G., Rindby A. and Selin E. (1982) Acta. Med. Scand 211: 493–499.PubMedCrossRefGoogle Scholar
  30. Orndahl G., Rindby A. and Selin E. (1983) Acta. Med. Scand. 213: 237–239.PubMedCrossRefGoogle Scholar
  31. Orndahl G., Seliden U., Hallin S., Wetterqvist H., Rindby A. and Selin E. (1986) Acta. Med. Scand. 219: 407–414.PubMedCrossRefGoogle Scholar
  32. Phoenix J., Edwards R.H.T. and Jackson M.J. (1989) Biochem. J. 287:207–213.Google Scholar
  33. Roelfs R.I., De Arango G.S., Law P.K. et al. (1979) Arch. Neurol. Neurosurg. Psych. 14: 95–100.Google Scholar
  34. Stern L.Z., Ringel S.P., Ziter F.A. et al. (1982) Arch. Neurol. 39: 342–346.PubMedCrossRefGoogle Scholar
  35. Thompson W.H.S and Smith I. (1978) Metabolism 27: 151–163.CrossRefGoogle Scholar
  36. Westeπnark T. (1977) Acta. Pharmacol, et. Toxicol. 41: 121–128.Google Scholar

Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • M. J. Jackson
    • 1
  • R. H. T. Edwards
    • 1
  1. 1.Department of MedicineUniversity of LiverpoolLiverpoolUK

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