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The Adult Respiratory Distress Syndrome (ARDS) and Oxidative Stress: Therapeutic Implications

  • Carroll E. Cross
  • Balz Frei
  • Samuel Louie
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)

Abstract

ARDS is an important acute clinical disorder of the lung, the pathogenesis of which is still incompletely understood. Evidence from in vitro studies, from experimental animal models, and from some clinical studies, suggest that oxidants may play a contributory role, possibly by mediating direct cellular injury or initiating or pertubating interactive inflammatory processes which lead to cell injury and leakage of blood components into the lung interstitial space and alveoli. Further investigations to define the contributions of oxidants and the efficacy of antioxidant administration will be needed before antioxidant therapies are routinely used to bolster what has been largely supportive care for patients with ARDS.

Keywords

Lung Injury Acute Lung Injury Xanthine Oxidase Adult Respiratory Distress Syndrome Arachidonic Acid Metabolite 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Carroll E. Cross
    • 1
  • Balz Frei
    • 2
  • Samuel Louie
    • 1
  1. 1.Department of MedicineUniversity of CaliforniaDavisUSA
  2. 2.Department of BiochemistryUniversity of CaliforniaBerkeleyUSA

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