Antioxidant Therapy in Hematological Disorders
Numerous investigations indicate the involvement of free radical reactions in the pathogenesis of hemolytic diseases; i.e. in vitamin E deficiency, abnormal glutathione metabolism, decreased NADPH production (e.g. glucose-6-phosphate dehydrogenase deficiency), catalase deficiency, sickle cell disease, thalassemia, and paroxysmal nocturnal hemoglobinuria (1–3). Other conditions leading to free radical mediated anemia may be the anemia of chronic renal failure and Fanconi–s anemia. Many drugs induce oxidative hemolysis in both normal individuals (4) and in patients with a defect in red cell antioxidant capa city, such as glucose-6-phosphate dehydrogenase (G-6-PD) deficiency and vitamin E deficiency. The majority of these drugs are aromatic compounds containing amino, nitro, or hydroxy groups. Clinical studies with antioxidants treating free radical-mediated hemolysis are quite numerous. However, reports with valuable trials are rare. Therefore, only a few studies are presented here with results, obtained with patients suffering from G-6-PD deficiency and anemia of chronic renal failure who were treated with either vitamin E or deferoxamine.
KeywordsParoxysmal Nocturnal Hemoglobinuria Chelation Therapy Iron Chelation Therapy Fava Bean Tocopheryl Acetate
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