Effect of the Platelet-Activating Factor (PAF) Antagonist, BN 52021, on Free Radical-Induced Intestinal Ischemia-Reperfusion Damage in the Rat

  • Marie-Thérèse Droy-Lefaix
  • Yvette Drouet
  • Gérard Géraud
  • Pierre Braquet
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 264)


During ischemia-reperfusion, oxygen-derived free radicals mediate tissue injury.1–21 The sources of oxygen-free radicals might include mucosal oxidases and activated polymorphonuclear leukocytes (PMNLs).7,11,20


Polymorphonuclear Neutrophil Ileal Mucosa Intestine Mucosal Damage Intestinal Reperfusion Mediate Tissue Injury 
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Copyright information

© Plenum Press, New York 1990

Authors and Affiliations

  • Marie-Thérèse Droy-Lefaix
    • 1
  • Yvette Drouet
    • 1
  • Gérard Géraud
    • 1
  • Pierre Braquet
    • 1
  1. 1.I.H.B./IPSEN Research LaboratoriesLe Plessis RobinsonFrance

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